The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis

R. Bedir, Bedir R, I. Sehitoglu, Sehitoglu I, Balik G, G. Balik, Mehmet Kağıtçı, M. Kagitci, Gucer H, H Gucer, Yurdakul C, Cüneyt Yurdakul, C Yurdakul, Pelin Bağcı, P Bagci, Bagci P
Clinical and experimental obstetrics & gynecology · 2016 · vol. 43(3) , pp. 463–466 · doi:10.12891/ceog2150.2016 · PMID:27328518 · W2466778283
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Nectin-4 expression was significantly higher in endometriotic lesions and eutopic endometrium of endometriosis patients compared to controls, suggesting a role in endometriosis pathogenesis.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

The paper investigated whether the adhesion molecule Nectin-4 is differentially expressed in normal endometrium versus ectopic endometriotic tissues. Using immunohistochemistry, it compared Nectin-4 expression across ovarian endometriosis (n=20), peritoneal endometriosis (n=20), endometrium of endometriosis (n=20), and a control group without endometriosis (n=20). Nectin-4 expression was higher in ovarian and peritoneal endometriotic lesions than in controls, and the difference was also significant in the endometrium of patients with endometriosis. The authors’ main limitation is that the study reports comparative expression without additional mechanistic experiments to establish causality, and it does not test Nectin-4-targeted interventions. This paper is centrally about endometriosis—focusing on Nectin-4 expression as a potential contributor to endometriosis pathogenesis.

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Abstract

OBJECTIVE: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. MATERIALS AND METHODS: Nectin-4 expression was investigated in ovarian endometriosis (n = 20), peritoneal endometriosis (n = 20), endometrium of endometriosis (n = 20), and in a control group (having no endometriosis) (n = 20) by immunohistochemical method. RESULTS: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). CONCLUSION: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.
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Abstract

Objective: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. Materials and Methods: Nectin-4 expression was investigated in ovarian endometriosis (n=20), peritoneal endometriosis (n=20), endometriumof endometriosis (n=20), and in a control group (having no endometriosis) (n=20) by immunohistochemical method. Results: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). Conclusion: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.

Keywords

- Endometriosis - Nectin-4 - Immunohistochemistry

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Condition tags

endometriosis

MeSH descriptors

Cell Adhesion Molecules Endometriosis Endometrium Ovarian Diseases Peritoneal Diseases Adult Case-Control Studies Cell Adhesion Molecules Endometriosis Endometrium Female Humans Immunohistochemistry Middle Aged Nectins Ovarian Diseases Peritoneal Diseases

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