The role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis

R Bedir, I Sehitoglu, G Balik, M Kagitci, H Gucer, Cüneyt Yurdakul, C Yurdakul, P Bagci, Pelin Bağcı
Clinical and experimental obstetrics & gynecology · 2016 · vol. 43(3) , pp. 463–466 · doi:10.12891/ceog2150.2016 · PMID:27328518 · W2466778283
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Abstract

OBJECTIVE: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. MATERIALS AND METHODS: Nectin-4 expression was investigated in ovarian endometriosis (n = 20), peritoneal endometriosis (n = 20), endometrium of endometriosis (n = 20), and in a control group (having no endometriosis) (n = 20) by immunohistochemical method. RESULTS: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). CONCLUSION: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.

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Condition tags

endometriosis

MeSH descriptors

Cell Adhesion Molecules Endometriosis Endometrium Ovarian Diseases Peritoneal Diseases Adult Case-Control Studies Cell Adhesion Molecules Endometriosis Endometrium Female Humans Immunohistochemistry Middle Aged Nectins Ovarian Diseases Peritoneal Diseases

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