{"paper_id":"3ebbf1ba-1504-4778-96b4-22faaf2f3cff","body_text":"Clinical and Experimental Obstetrics & Gynecology (CEOG) is published by IMR Press from Volume 47 Issue 1 (2020). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with S.O.G.\nThe role of the adhesion molecule Nectin-4 in the pathogenesis of endometriosis\nAffiliations\nArticle Info\n1 Recep Tayyip Erdogan University, Faculty of Medicine, Department of Pathology, Rize\n2 Recep Tayyip Erdogan University, Faculty of Medicine, Department of Obstetrics and Gynecology, Rize\n3 Marmara University, Faculty of Medicine, Department of Pathology, Istanbul (Turkey)\nAbstract\nObjective: Nectins are immunoglobulin-like adhesion molecules, and they play important role in cell proliferation and tumor metastasis. The objective in this study was to compare the expression of Nectin-4 in normal endometrium and in ectopic endometriotic tissues. Materials and Methods: Nectin-4 expression was investigated in ovarian endometriosis (n=20), peritoneal endometriosis (n=20), endometriumof endometriosis (n=20), and in a control group (having no endometriosis) (n=20) by immunohistochemical method. Results: Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis (p = 0.003 and p = 0.009, respectively). This difference was significant in the endometrium of patients having endometriosis (p = 0.011). Conclusion: The authors believe that Nectin-4 molecule may contribute to the pathogenesis of endometriosis. For this reason, the use of medicines developed against this molecule in the treatment of endometriosis may be useful.\nKeywords\n- Endometriosis\n- Nectin-4\n- Immunohistochemistry","source_license":"CC0","license_restricted":false}