Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9
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Metformin treatment in rats led to regression of endometriotic implants by modulating key molecules involved in oxidative stress, angiogenesis, and extracellular matrix remodeling.
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Cited by (41)
- Emerging signal transduction pathways and the role of bacterial extracellular vesicles linked to the pathogenesis of endometriosis 2026
- Letrozole plus metformin versus letrozole alone in the treatment of symptomatic endometrioma 2025
- Effects of pentoxifylline and metformin combination therapy compared to metformin alone in infertile women with symptomatic endometrioma 2024
- Beneficial biological effects of Flavokawain A, a chalcone constituent from kava, on surgically induced endometriosis rat model 2023
- Effects of metformin and ganirelix on subcutaneous endometriosis in a mouse model of autophagy-related cell death 2023
- Metformin Inhibits the Estrogen-mediated Epithelial-Mesenchymal Transition of Ectopic Endometrial Stromal Cells in Endometriosis 2023
- Synthetic flavokawain analog (E)-1-(2′-hydroxy-4′,6′-dimethoxyphenyl)-3-(3-methoxy-4-(3-morpholinopropoxy)phenyl)prop-2-en-1-one (FK-morph) effectively regresses endometriotic implants in rats 2022
- Medical treatments of endometriosis: a review 2022
- Antilipidemic ezetimibe induces regression of endometriotic explants in a rat model of endometriosis with its anti-inflammatory and anti-angiogenic effects 2022
- Metformin Alleviates Endometriosis and Potentiates Endometrial Receptivity via Decreasing VEGF and MMP9 and Increasing Leukemia Inhibitor Factor and HOXA10 2022
- Metformin as a Potential Treatment Option for Endometriosis 2022
- Anti-oxidant effect of metformin through AMPK/SIRT1/PGC-1α/SIRT3– independent GPx1 expression in the heart of mice with endometriosis 2022
- The latest advances in the pharmacological management of endometriosis 2022
- Metformin Prevents Endothelial Dysfunction in Endometriosis through Downregulation of ET-1 and Upregulation of eNOS 2022
- Immunosuppression and immunotherapy in endometriosis 2021
- Metformin attenuates expression of angiogenic and inflammatory genes in human endometriotic stromal cells 2021
- Changing prostaglandin E2 (PGE<sub>2</sub>) signaling during lesional progression and exacerbation of endometriosis by inhibition of PGE<sub>2</sub> receptor EP2 and EP4 2021
- Role of medical treatment of endometriosis 2021
- Metformin Efficiency in Genital Endometriosis Management 2021
- Effect of Metformin on Bcl-2/Bax Expression Ratio and Endometrial Implants: A Mouse Model in Endometriosis Study 2020
- Co-morbidity of type 1 diabetes and endometriosis: bringing a new paradigm into focus 2019
- The Difference of Integrin ανβ3 Expression, Leukemia Inhibitory Factors and Superoxide Dismutase Serum Concentration in the Provision of Kebar Extract (Biophytum petersianum Klotczh), Metformin, and Their Combination to Mouse models of Endometriosis 2018
- Investigational drugs for the treatment of endometriosis, an update on recent developments 2018
- Comparative assessment of effectiveness of new drugs for targeted therapy of endometriosis by experimental model 2018
- Vascularization in endometriosis and its clinical applications 2018
- Comparative assessment of effectiveness of new drugs for targeted therapy of endometriosis by experimental model 2018
- Current and emerging treatment options for endometriosis 2018
- Prospects of metformin in the treatment of endometriosis 2017
- Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics 2016
- Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis? 2016
- An overview of early drug development for endometriosis 2015
- Management of Endometriosis 2015
- Non‐hormonal targets underlying endometriosis: A focus on molecular mechanisms 2015
- Metformin regulates stromal-epithelial cells communication via Wnt2/β-catenin signaling in endometriosis 2015
- Novel Medical Treatment Modalities of Endometriosis 2015
- Physicochemistry of dinitrosyl iron complexes with thiolate ligands underlying their beneficial effect in endometriosis 2014
- Melatonin causes regression of endometriotic implants in rats by modulating angiogenesis, tissue levels of antioxidants and matrix metalloproteinases 2014
- Dinitrosyl iron complexes with glutathione suppress experimental endometriosis in rats 2014
- Comparison of antiproliferative effects of metformine and progesterone on estrogen-induced endometrial hyperplasia in rats 2013
- The Effects of Ranibizumab on Surgically Induced Endometriosis in a Rat Model: A Preliminary Study 2013
- Endometriosis and Angiogenic Factors 2012
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- pubmed
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