Metformin attenuates expression of angiogenic and inflammatory genes in human endometriotic stromal cells

Simin Yari; Heidar Heidari Khoei; Maryam Saber; Fereshteh Esfandiari; Ashraf Moini; Maryam Shahhoseini

doi:10.1016/j.yexcr.2021.112659

Metformin attenuates expression of angiogenic and inflammatory genes in human endometriotic stromal cells

Simin Yari, Heidar Heidari Khoei, Maryam Saber, Fereshteh Esfandiari, Ashraf Moini, Maryam Shahhoseini

Experimental cell research · 2021 · vol. 404(2) , pp. 112659 · doi:10.1016/j.yexcr.2021.112659 · PMID:34022204 · W3163766363

article OA: closed CC0 ⤵ 4 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Metformin was found to reduce the expression of genes related to angiogenesis and inflammation in human endometriotic stromal cells.

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Condition tags

endometriosis

MeSH descriptors

Endometrium Metformin Neovascularization, Pathologic Stromal Cells Cell Movement Cell Movement Cell Movement Cell Proliferation Cell Proliferation Cell Proliferation Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Endometrium Epithelial Cells Epithelial Cells Epithelial Cells Female

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References (27)

Association between macrophage migration inhibitory factor in the endometrium and estrogen in endometriosis via openalex
Endometriosis via openalex
Endometriosis and Risk of Adverse Pregnancy Outcomes via openalex
Expression of MMIF, HIF-1α and VEGF in Serum and Endometrial Tissues of Patients with Endometriosis via openalex
Expression of vascular endothelial growth factor A isoforms is dysregulated in women with endometriosis via openalex
Increased Circulating MMP-2 Levels in Infertile Patients With Moderate and Severe Pelvic Endometriosis via openalex
Is Endometriosis More Common and More Severe Than It Was 30 Years Ago? via openalex
Macrophage migration inhibitory factor as a potential biomarker of endometriosis via openalex
Matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of matrix metalloproteinases (TIMP-1) and transforming growth factor-β2 (TGF-β2) expression in eutopic endometrium of women with peritoneal endometriosis via openalex
Metformin as a new therapy for endometriosis, its effects on both clinical picture and cytokines profile via openalex
Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis via openalex
Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9 via openalex
Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis via openalex
Rethinking mechanisms, diagnosis and management of endometriosis via openalex
The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex
The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression via openalex
W6715081954 via openalex
W2026967508 via openalex
W2055452548 via openalex
W2057298326 via openalex
W2057684012 via openalex
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W2125747634 via openalex
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W2410880911 via openalex
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W6683013767 via openalex

Cited by (4)

Source provenance

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openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-13T22:24:37.768885+00:00
unpaywall: last seen: 2026-06-13T06:42:57.164913+00:00

License: CC0 · commercial use OK

[1] Association between macrophage migration inhibitory factor in the endometrium and estrogen in endometriosis via openalex

[2] Endometriosis via openalex

[3] Endometriosis and Risk of Adverse Pregnancy Outcomes via openalex

[4] Expression of MMIF, HIF-1α and VEGF in Serum and Endometrial Tissues of Patients with Endometriosis via openalex

[5] Expression of vascular endothelial growth factor A isoforms is dysregulated in women with endometriosis via openalex

[6] Increased Circulating MMP-2 Levels in Infertile Patients With Moderate and Severe Pelvic Endometriosis via openalex

[7] Is Endometriosis More Common and More Severe Than It Was 30 Years Ago? via openalex

[8] Macrophage migration inhibitory factor as a potential biomarker of endometriosis via openalex

[9] Matrix metalloproteinase-2 (MMP-2), MMP-9, tissue inhibitor of matrix metalloproteinases (TIMP-1) and transforming growth factor-β2 (TGF-β2) expression in eutopic endometrium of women with peritoneal endometriosis via openalex

[10] Metformin as a new therapy for endometriosis, its effects on both clinical picture and cytokines profile via openalex

[11] Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis via openalex

[12] Metformin regresses endometriotic implants in rats by improving implant levels of superoxide dismutase, vascular endothelial growth factor, tissue inhibitor of metalloproteinase-2, and matrix metalloproteinase-9 via openalex

[13] Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis via openalex

[14] Rethinking mechanisms, diagnosis and management of endometriosis via openalex

[15] The effects of metformin and letrozole on endometriosis and comparison of the two treatment agents in a rat model via openalex

[16] The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis: Basic science and new insights based on gene expression via openalex

[17] W6715081954 via openalex

[18] W2026967508 via openalex

[19] W2055452548 via openalex

[20] W2057298326 via openalex

[21] W2057684012 via openalex

[22] W2093664485 via openalex

[23] W2125747634 via openalex

[24] W2198636128 via openalex

[25] W2410880911 via openalex

[26] W6660617731 via openalex

[27] W6683013767 via openalex