The Effects of Ranibizumab on Surgically Induced Endometriosis in a Rat Model: A Preliminary Study

Objective To examine the effect of ranibizumab on surgically induced endometriosis in rat models. Study Design Endometrial tissue was implanted onto the abdominal peritoneum of 20 rats that were randomized into 2 groups. The rats in group 1 (n = 9) were given 0.6 mg/kg ranibizumab on the 1st and 14th days after the second operation. The rats in group 2 (control group, n = 9) received no medication. All the rats were observed for a total of 28 days.

At the end of the treatment, the mean volume and weight of the explants in group 1 (11.49 ± 6.87 mm3 and 36.61 ± 17.84 mg) were significantly lower than that of the control group (190.6 ± 177.4 mm3 and 187.3 ± 174.5 mg; both Ps < .01). Mean epithelial histologic scores were significantly lower in group 1 (1.11 ± 0.78) than that of the control group (2.33 ± 0.71; P < .01). When compared with the control group, vascular endothelial growth factor (VEGF) immunoreactivities in group 1 showed statistically significant reductions (1.67 ± 0.50; 2.67 ± 0.50; P < .01).

Ranibizumab has significantly regressed the size of the endometriotic implants and caused atrophy of these lesions in rats by decreasing explant levels of VEGF. Similar content being viewed by others

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Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Sevket, O., Sevket, A., Buyukpinarbasili, N. et al. The Effects of Ranibizumab on Surgically Induced Endometriosis in a Rat Model: A Preliminary Study. Reprod. Sci. 20, 1224–1229 (2013). https://doi.org/10.1177/1933719113483012 Published: Issue date: DOI: https://doi.org/10.1177/1933719113483012