Vascular development in endometriosis

P G Groothuis, Patrick G. Groothuis, Annemiek Nap, A W Nap, E Winterhager, Elke Winterhager, R Grümmer, Ruth Grümmer
Angiogenesis · 2005 · vol. 8(2) , pp. 147–156 · doi:10.1007/s10456-005-9005-x · PMID:16211360 · W2062146531
review OA: closed CC0 ⤵ 135 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This review discusses the current understanding of angiogenesis's role in the ectopic implantation and survival of menstrual endometrial tissue in endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This paper reviews evidence that angiogenesis is necessary for the development and persistence of endometriosis, focusing on how ectopic menstrual endometrial tissue implants and survives outside the uterus. It draws on state-of-the-art findings across mechanisms of blood vessel growth, including VEGF regulation, hypoxia-related pathways, macrophage and inflammatory influences, and related angiogenic factors, along with experimental and therapeutic data such as antiangiogenesis approaches. A key limitation is that it is a narrative review that synthesizes evidence rather than presenting new primary data, so causal mechanisms and relative contributions of factors may not be fully resolved. This paper is centrally about endometriosis — it specifically reviews the role of angiogenesis in ectopic implantation and survival of menstrual endometrial tissue.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Blood Vessels Endometriosis Endometrium Endometrium Neovascularization, Pathologic Blood Vessels Blood Vessels Cell Movement Cell Movement Endometriosis Endometrium Female Humans Neovascularization, Pathologic Plasminogen Activators Plasminogen Activators Plasminogen Inactivators Plasminogen Inactivators

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

europepmc
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License: CC0 · commercial use OK