Elevated Serum CD95/FAS and HIF-1α Levels, but Not Tie-2 Levels, May Be Biomarkers in Patients With Severe Endometriosis: A Preliminary Report

Savaş Karakuş, Savas Karakus, Karakus S, Enver Sancakdar, Sancakdar E, Akkar O, Ozlem Akkar, Özlem Bozoklu Akkar, Çağlar Yıldız, Yildiz C, Caglar Yildiz, Özlem Demirpençe, Demirpence O, Ozlem Demirpence, Ali Cetin, Ali Çetin
Journal of Minimally Invasive Gynecology · 2016 · vol. 23(4) , pp. 573–577 · doi:10.1016/j.jmig.2016.01.025 · PMID:26851415 · W2254587346
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This preliminary report investigated serum levels of CD95/FAS, HIF-1α, and Tie-2 in severe endometriosis patients, finding elevated CD95/FAS and HIF-1α but not Tie-2.

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Abstract

Study objectiveTo evaluate serum values of cluster of differentiation 95 (CD95/FAS), hypoxia-inducible factor 1-alpha (HIF-1α), and tyrosine kinase receptor 2 (Tie-2) as possible biomarkers of disease presence and severity in women with endometriosis, and to characterize the changes in these values in women with stage I/II and stage III/IV endometriosis.DesignProspective study (Canadian Task Force classification I).SettingUniversity hospital.PatientsThirty women with endometriosis and 30 healthy women without endometriosis.InterventionFor the diagnosis of endometriosis and prediction of its severity, we measured the serum levels of CD95/FAS, which assess apoptotic conditions, and of HIF-1α and Tie-2, which assess angiogenesis. Endometriosis was diagnosed and staged through surgical laparoscopy and later confirmed histologically. During the surgery, the patients with endometriosis were divided into 2 groups based on disease stage. Eleven patients had stage I/II endometriosis, and 19 had stage III/IV endometriosis.Measurements and main resultsEndometriosis was associated with increased serum CD95/FAS and HIF-1α levels, but not Tie-2 levels. We also determined that stage III/IV endometriosis was associated with higher serum CD95/FAS and HIF-1α levels, but not Tie-2 levels, compared with stage I/II endometriosis.ConclusionEndometriosis, in accordance with its severity, increases serum CD95/FAS and HIF-1α levels, but not Tie-2 levels. These biomarkers may be useful for reproductive surgeons to improve the quality of counseling women about the presence and severity of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis fas Receptor Hypoxia-Inducible Factor 1, alpha Subunit Receptor, TIE-2 Adult Biomarkers Biomarkers Case-Control Studies Endometriosis Endometriosis Endometriosis fas Receptor Female Humans Hypoxia-Inducible Factor 1, alpha Subunit Middle Aged Neovascularization, Pathologic Predictive Value of Tests Prospective Studies Receptor, TIE-2

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