Noninvasive diagnosis of endometriosis: Review of current peripheral blood and endometrial biomarkers

O DF, Dorien F O, Idhaliz Flores, Flores I, Waelkens E, Etienne Waelkens, Thomas D'Hooghe, Thomas D’Hooghe, D'Hooghe T
Best practice & research. Clinical obstetrics & gynaecology · 2018 · vol. 50 , pp. 72–83 · doi:10.1016/j.bpobgyn.2018.04.001 · PMID:29778458 · W2797180358
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This review examines current peripheral blood and endometrial biomarkers for the noninvasive diagnosis of endometriosis.

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Abstract

A noninvasive biomarker-based test could help shorten the diagnostic delay for endometriosis. The most investigated biomarker sources are peripheral blood and endometrium. Discovery of endometriosis biomarkers is often hypothesis-driven, i.e. when one or a few biomarkers are investigated based on their role in the disease pathogenesis. Alternatively, a hypothesis-generating approach has been followed using the "omics" technologies. A variety of biomarkers for endometriosis have been investigated, but no biomarker has been validated for clinical use. Many challenges lie ahead in the endometriosis biomarker field. In the future, harmonized collection and reporting methods should allow large-scale international collaboration for highly powered studies.

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Condition tags

endometriosis

MeSH descriptors

Biomarkers Diagnostic Techniques, Obstetrical and Gynecological Endometriosis Biomarkers CA-125 Antigen CA-125 Antigen Diagnostic Techniques, Obstetrical and Gynecological Endometriosis Endometrium Endometrium Female Galectins Galectins Glycodelin Glycodelin Humans Inflammation Mediators Inflammation Mediators Reactive Oxygen Species Reactive Oxygen Species

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (90)

Cited by (41)

Source provenance

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License: CC0 · commercial use OK