Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages

Dilşan Kızılgedik, Armağan Caner, Çağlar Yıldız, Buğra Okasoğlu, Sema Mısır, İlhan Yaylım, Semra Demokan, Ceylan Hepokur
In: Experimed · 2023 · vol. 13(1) , pp. 15–20 · doi:10.26650/experimed.1148905 · W4366412475
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study measured serum Galectin-3 and CA-125, and Gal-3 expression via qRT-PCR, finding significantly higher Gal-3 levels in endometriosis patients compared to controls.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-11 · read from full text ⓘ

The paper investigates galectin-3 levels in patients with endometriosis, stratifying measurements by disease stage. It examines how galectin-3 varies across these stages to characterize whether this biomarker tracks with progression. A key limitation is that the provided text contains only non-substantive website cookie/data-policy language and does not include the study’s actual methods, results, sample details, or explicitly stated caveats. This paper is centrally about endometriosis — it specifically measures galectin-3 levels according to endometriosis stages.

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Abstract

Objective: Endometriosis is a gynecological disease associated with chronic pelvic inflammation, pain, and infertility. Galectin-3 (Gal-3) is a protein that can bind to β-galactosides, which plays an important role in different biological processes according to the stages of the disease in patients with endometriosis. This study aimed to elucidate the importance of Gal-3 in endometriosis, to reveal its potential power as a non-invasive diagnostic biomarker in disease etiopathogenesis.Materials and Methods: The serum concentration of Gal-3 and cancer antigen 125 (CA-125) from whole blood were measured using enzyme-linked immuno sorbent assay (ELISA) and an auto-analyzer, respectively. Gal-3 expression was determined by quantitative real-time polymerase chain reaction (qRT-PCR) from peripheral blood.Results: We found significant differences for Gal-3 expression levels between the endometriosis and control groups (p <0.05). Gal-3 levels in the serum of women with endometriosis are also remarkably increased compared with the control group.Conclusion: Galectin-3 can play critical functions in the development and progression of endometriosis, so, further studies are needed in this area
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Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

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