Investigation of Galectin-3 Levels of Endometriosis Patients According to Stages

Dilşan Kızılgedik, Armağan Caner, Çağlar Yıldız, Buğra Okasoğlu, Sema Mısır, İlhan Yaylım, Semra Demokan, Ceylan Hepokur
In: Experimed · 2023 · vol. 13(1) , pp. 15–20 · doi:10.26650/experimed.1148905 · W4366412475
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This study measured serum Galectin-3 and CA-125, and Gal-3 expression via qRT-PCR, finding significantly higher Gal-3 levels in endometriosis patients compared to controls.

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Abstract

Objective: Endometriosis is a gynecological disease associated with chronic pelvic inflammation, pain, and infertility. Galectin-3 (Gal-3) is a protein that can bind to β-galactosides, which plays an important role in different biological processes according to the stages of the disease in patients with endometriosis. This study aimed to elucidate the importance of Gal-3 in endometriosis, to reveal its potential power as a non-invasive diagnostic biomarker in disease etiopathogenesis.Materials and Methods: The serum concentration of Gal-3 and cancer antigen 125 (CA-125) from whole blood were measured using enzyme-linked immuno sorbent assay (ELISA) and an auto-analyzer, respectively. Gal-3 expression was determined by quantitative real-time polymerase chain reaction (qRT-PCR) from peripheral blood.Results: We found significant differences for Gal-3 expression levels between the endometriosis and control groups (p <0.05). Gal-3 levels in the serum of women with endometriosis are also remarkably increased compared with the control group.Conclusion: Galectin-3 can play critical functions in the development and progression of endometriosis, so, further studies are needed in this area

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endometriosisinfertility

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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