Intercellular adhesion molecule-1 (ICAM-1) gene polymorphism and endometriosis in northern Iran

Purpose Endometriosis is a chronic pleomorphic disorder with pelvic or systemic manifestations, and is characterized by the presence of endometrial glands and stroma. It is generally considered to involve genetic, environmental, immunological, angiogenic and endocrine processes. The aim of this study was to evaluate the frequency of intercellular adhesion molecule-1 (ICAM-1) polymorphism at position 241 in exon 4 of the ICAM-1 gene in patients with endometriosis and in healthy control subjects in northern Iran.

A total of 84 unrelated patients and 120 consecutive unrelated healthy controls from the northern Iran were recruited for the study. ICAM-1 codon 241 polymorphism analysis was performed by two independent PCR reactions, based on the two set of oligoprimers specific for Arg (AGG) or Gly (GGG) coding sequence, respectively.

Genotype distributions of ICAM-1 gene show significant difference between patients and controls. The R241 allele was detected in 23% of endometriosis patients and in 6% of controls (P = 0.001; odds ratio 4.67; 95% confidence interval 1.81–12.07). Comparing patients with different stage of endometriosis, we found a trend to higher frequency of R241 in patients with stage IV (65 vs 6%; P < 0.0001).

Our results suggest that ICAM-1 polymorphism in codon 241 is associated with the development of endometriosis susceptibility in the population of northern Iran. Similar content being viewed by others

Halis G, Arici A (2004) Endometriosis and inflammation in infertility. Ann N Y Acad Sci 1034:300–315 Fauconnier A, Chapron C (2005) Endometriosis and pelvic pain: epidemiological evidence of the relationship and implications. Hum Reprod Update 11:595–606 Varma R, Rollason T, Gupta JK, Maher ER (2004) Endometriosis and the neoplastic process. Reproduction 127:293–304 Sampson JA (1927) Peritoneal endometriosis due to the menstrual dissemination of endometrial tissues into the peritoneal cavity. Am J Obstet Gynecol 14:422–469 Hsieh YY, Chang CC, Tsai FJ, Peng CT, Yeh LS, Lin CC (2005) Polymorphism for transforming growth factor beta 1–509 (TGF-B1–509): association with endometriosis. Biochem Genet 43:203–210 Vigano P, Infantino M, Lattuada D, Lauletta R, Ponti E, Somigliana E et al (2003) Intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms in endometriosis. Mol Hum Reprod 9:47–52 Teramoto M, Kitawaki J, Koshiba H, Kitaoka Y, Obayashi H, Hasegawa G et al (2004) Genetic contribution of tumor necrosis factor (TNF)-alpha gene promoter (−1031, −863 and −857) and TNF receptor 2 gene polymorphisms in endometriosis susceptibility. Am J Reprod Immunol 51:352–357 Hopkins AM, Baird AW, Nusrat A (2004) ICAM-1: targeted docking for exogenous as well as endogenous ligands. Adv Drug Deliv Rev 19:763–778 Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA (1986) Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 137:245–254 Simmons D, Makgoba MW, Seed B (1988) ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature (London) 331:624–627 Marlin SD, Springer TA (1989) Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51:813–819 Landis RC, McDowall A, Holness CLL, Littler AJ, Simmons DL, Hogg N (1994) Involvement of the “I” domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3. J Cell Biol 126:529–537 Diamond MS, Garcia-Aguilar J, Bickford JK, Corbi AL, Springer TA (1993) The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands. J Cell Biol 120:1031–1043 Staunton DE, Dustin ML, Erickson HP, Springer TA (1990) The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell 61:243–254 McClelland A, deBear J, Yost SC, Meyer AM, Marlor CW, Greve JM (1991) Identification of monoclonal antibody epitopes and critical residues for rhinovirus binding in domain 1 of intercellular adhesion molecule 1. Proc Natl Acad Sci USA 88:7993–7997 Vora DK, Rosenbloom CL, Beaudet AL, Cottingham RW (1994) Polymorphisms and linkage analysis for ICAM-1 and the selectin gene cluster. Genomics 21:473–477 Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA (1988) Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52:925–933 Diamond MS, Staunton DE, Marlin SD, Springer TA (1991) Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell 65:961–971 McLaren AJ, Marshall SE, Haldar NA, Mullighan CG, Fuggle SV, Morris PJ et al (1999) Adhesion molecule polymorphisms in chronic renal allograft failure. Kidney Int 55:1977–1982 Amoli MM, Mattey DL, Calviño MC, Garcia-Porrua C, Thomson W, Hajeer AH et al (2001) Polymorphism at codon 469 of the intercellular adhesion molecule-1 locus is associated with protection against severe gastrointestinal complications in Henoch–Schonlein purpura. J Rheumatol 28:1014–1018 Macchioni P, Boiardi L, Casali B, Nicoli D, Farnetti E, Salvarani C (2000) Intercellular adhesion molecule 1 (ICAM-1) gene polymorphisms in Italian patients with rheumatoid arthritis. Clin Exp Rheumatol 18:553–558 Marrosu MG, Schirru L, Fadda E, Mancosu C, Lai M, Cocco E et al (2000) ICAM-1 gene is not associated with multiple sclerosis in Sardinian patients. J Neurol 247:677–680 Boiardi L, Salvarani C, Casali B, Olivieri I, Ciancio G, Cantini F et al (2001) Intercellular adhesion molecule-1 gene polymorphisms in Behcet’s Disease. J Rheumatol 28:1283–1287 Braun C, Zahn R, Martin K, Albert E, Folwaczny C (2001) Polymorphisms of the ICAM-1 gene are associated with inflammatory bowel disease, regardless of the p-ANCA status. Clin Immunol 101:357–360 Yang H (1997) Analysis of ICAM-1 gene polymorphism in immunologic subsets of inflammatory bowel disease. Exp Clin Immunogenet 14:214–225 Salvarani C, Casali B, Boiardi L, Ranzi A, Macchioni P, Nicoli D et al (2000) Intercellular adhesion molecule 1 gene polymorphisms in polymyalgia rheumatica/giant cell arteritis: association with disease risk and severity. J Rheumatol 27:1215–1221 Wenzel K, Ernst M, Rohde K, Baumann G, Speer A (1996) DNA polymorphisms in adhesion molecule genes–a new risk factor for early atherosclerosis. Hum Genet 97:15–20 Yamashita M, Yoshida S, Kennedy S, Ohara N, Motoyama S, Maruo T (2005) Association study of endometriosis and intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms in a Japanese population. J Soc Gynecol Investig 12:267–271 Acknowledgments This study was supported by the University of Guilan. The authors thank all people in the Genetics and Developmental Biology Laboratories, Department of Biology, Faculty of Sciences, University of Guilan, for their technical assistance. Conflict of interest statement None. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Aghajanpour, L., Mashayekhi, F. & Rajaei, F. Intercellular adhesion molecule-1 (ICAM-1) gene polymorphism and endometriosis in northern Iran. Arch Gynecol Obstet 283, 1035–1039 (2011). https://doi.org/10.1007/s00404-010-1479-0 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-010-1479-0