Association Study of Endometriosis and Intercellular Adhesion Molecule-1 (ICAM-1) Gene Polymorphisms in a Japanese Population

Masako Yamashita, Yamashita M, Shigeki Yoshida, Yoshida S, Kennedy S, Stephen Kennedy, Noriyuki Ohara, Ohara N, Satoru Motoyama, Motoyama S, Maruo T, Takeshi Maruo
Journal of the Society for Gynecologic Investigation · 2005 · vol. 12(4) , pp. 267–271 · doi:10.1016/j.jsgi.2005.03.002 · PMID:15866119 · W2002468220
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This study investigated associations between endometriosis and gene polymorphisms of intercellular adhesion molecule-1 (ICAM-1) in a Japanese population.

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Abstract

ObjectiveEndometriosis is an immune-related, chronic inflammatory disease with polygenic predisposition. Cell adhesion molecules are expressed in endometriotic lesions, and in cells and tissues that are involved in the development and progression of the disease. In this study, we investigated the possible association between endometriosis and the G241R and K469E polymorphisms in the intercellular adhesion molecule-1 (ICAM-1) gene in a Japanese population.MethodsWe compared the distribution of the G241R and K469E polymorphisms in the ICAM-1 gene in 126 endometriosis patients and 172 controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in a Japanese population.ResultsThere were no significant differences between the cases and controls in the allele frequencies or genotype distributions of either the G241R or K469E polymorphisms in the ICAM-1 gene. The endometriosis patients were divided into a subgroup of women with severe disease only. However, no significant differences were observed in the allele frequencies and genotype distributions of the ICAM-1 K469E polymorphisms between this subgroup and the controls. In contrast, only one in 169 controls was heterozygous (G/A genotype), and the A allele in the G241R polymorphism was not found in any of the 126 endometriosis patients.ConclusionOur findings suggest that the G241R and K469E polymorphisms in the ICAM-1 gene are unlikely to be associated with an increased risk of endometriosis in the Japanese population.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Intercellular Adhesion Molecule-1 Case-Control Studies Endometriosis Endometriosis Female Genetic Predisposition to Disease Genotype Humans Intercellular Adhesion Molecule-1 Japan Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length

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