Association of the intercellular adhesion molecule-1 (ICAM-1) gene polymorphisms with endometriosis: a systematic review and meta-analysis

Noel Pabalan, Hamdi Jarjanazi, Denise Maria Christofolini, Caio Parente Barbosa, Bianca Bianco
Archives of gynecology and obstetrics · 2015 · vol. 292(4) , pp. 843–851 · doi:10.1007/s00404-015-3705-2 · PMID:25859827 · W2056085796
review OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

A meta-analysis of six studies found that ICAM-1 gene polymorphisms are associated with an increased risk of endometriosis, particularly in Caucasians.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This paper conducted a systematic review and meta-analysis of six published case–control studies (from five articles) to assess whether ICAM-1 gene polymorphisms G241R and K469E are associated with endometriosis, estimating odds ratios across models (homozygous, dominant, codominant) using Review Manager 5.3. Across 1213 cases and 1103 controls, the overall analysis found significant increased risk under several genetic comparison models, but when restricted to studies in Hardy–Weinberg equilibrium the statistical significance disappeared; the authors also reported variable effects by ethnicity, with significant effects noted in Caucasian subgroups and non-significant/variable effects in Asian subgroups. They observed weak but non-heterogeneous findings (low I²), while explicitly noting limitations related to high heterogeneity and the reduced robustness after Hardy–Weinberg filtering. This paper is centrally about endometriosis — it meta-analyzes ICAM-1 (G241R and K469E) genetic polymorphisms as susceptibility markers for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Intercellular Adhesion Molecule-1 Asian People Asian People Case-Control Studies Endometriosis Female Genetic Predisposition to Disease Humans Intercellular Adhesion Molecule-1 Middle Aged Odds Ratio Polymerase Chain Reaction Polymorphism, Genetic Risk White People White People

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europepmc
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