Endometrial release of soluble intercellular adhesion molecule 1 and endometriosis: relationship to the extent of the disease

Paola Viganò, P Viganò, P Viganò, E Somigliana, B Gaffuri, R Santorsola, M Busacca, M Vignali
Obstetrics and gynecology · 2000 · vol. 95(1) , pp. 115–118 · doi:10.1016/s0029-7844(99)00465-2 · PMID:10636513 · W2133141847
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Endometrial release of soluble intercellular adhesion molecule 1 correlated with the number and score of endometriotic implants but not with adhesions, cyst size, pelvic pain, or prior surgery.

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Abstract

OBJECTIVE: To relate endometrial release of the soluble form of intercellular adhesion molecule 1 with extent of endometriosis. METHODS: Samples of endometrium were collected from 23 women with endometriosis. Soluble intercellular adhesion molecule 1 was quantified in conditioned medium from 48-hour endometrial stromal cell cultures with use of a specific enzyme-linked immunosorbent assay. Levels were correlated with revised American Society for Reproductive Medicine classification score for adhesions, implants, and cysts and total score; number of endometriotic implants; cyst diameter; and presence or absence of pelvic pain symptoms and previous surgical procedures for endometriosis. RESULTS: Endometrial release of soluble intercellular adhesion molecule 1 directly correlated with number of implants (r = .64, P < .005) and score for implants (r = .61, P < .005). There was no significant correlation between levels of the soluble molecule and score for adhesions or total score. Soluble intercellular adhesion molecule 1 shed by endometrium did not correlate with the score for ovarian cysts, although an inverse relationship was found with ovarian cyst diameter (r = -0.52, P < .05). No differences were detected between women who had pelvic pain and those who did not and between those who had previous surgery for endometriosis and those who had not. CONCLUSION: The association between endometrial release of soluble intercellular adhesion molecule 1 and the number and score of endometriotic implants suggests that the molecule might be of value in evaluating spread potential of refluxed endometrium.

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Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Endometriosis Endometrium Intercellular Adhesion Molecule-1 Adult Cells, Cultured Endometriosis Endometriosis Endometriosis Endometrium Enzyme-Linked Immunosorbent Assay Female Humans Intercellular Adhesion Molecule-1 Ovarian Cysts Ovarian Cysts Ovarian Cysts Pelvic Pain Pelvic Pain

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