Soluble ICAM-1 levels in the serum of endometriotic patients appear to be independent of medical treatment

I M Matalliotakis, Matalliotakis IM, Ioannis Matalliotakis, Vassiliadis S, S. Vassiliadis, Goumenou AG, A G Goumenou, Anastasia G. Goumenou, Irene Athanassakis, I Athanassakis, Athanassakis I, Koumantakis GE, G E Koumantakis, Georgios Koumantakis, M Neonaki, M A Neonaki, Neonaki MA, Evgenios Koumantakis, E E Koumantakis, Koumantakis EE
Journal of Reproductive Immunology · 2001 · vol. 51(1) , pp. 9–19 · doi:10.1016/s0165-0378(01)00064-x · PMID:11438377 · W2082288992
article OA: closed CC0 ⤵ 33 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated soluble ICAM-1 levels in the serum of endometriotic patients and found them to be independent of medical treatment.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Adhesion molecules regulate the interaction of cells with the extracellular matrix and/or other cells. The intercellular adhesion molecule-1 (ICAM-1; CD54) is a member of the immunoglobulin superfamily and expressed by several cell types, including leukocytes and endothelial cells. A circulating form of the usually membrane-bound molecule was identified and characterized in normal human serum and in sera from patients with endometriosis. In the present study, we established the serum-soluble ICAM-1 (sICAM-1) levels in patients with endometriosis. We also studied the effect of danazol and leuprorelin acetate depot on the levels of sICAM-1. Thirty-eight women, 18-45 years of age, with regular menses and documented pelvic endometriosis were recruited from a University Hospital setting. Twenty-two women with endometriosis were randomly divided into two groups. Danazol (600 mg) were given every day for 6 months, and 3.75 mg of leuprorelin acetate depot every 28 days for 6 months. Serum sICAM-1 concentrations were measured before, during and after treatment, and its quantitative determination was performed by an ELISA technique using a specific immunoassay. We found that (1) sICAM-1 levels were higher in women with endometriosis in comparison to healthy subjects; (2) the 6 month treatment with danazol or leuprorelin acetate depot increased sICAM-1 levels (P<0.001); (3) 3 months after termination of both treatments, sICAM-1 levels were unchanged. Although the mechanism leading to the increase of sICAM-1 needs to be further clarified, any benefits of medical treatment of endometriosis such as danazol or leuprorelin appear to be independent of changes in ICAM-1 serum levels.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Danazol Endometriosis Endometriosis Intercellular Adhesion Molecule-1 Leuprolide Adolescent Adult Danazol Endometriosis Estrogen Antagonists Estrogen Antagonists Female Fertility Agents, Female Fertility Agents, Female Humans Intercellular Adhesion Molecule-1 Leuprolide Middle Aged

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (33)

Source provenance

europepmc
last seen: 2026-08-12T06:07:16.479679+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:13:24.901228+00:00
License: CC0 · commercial use OK