PRL, TSH and Their Response to the TRH Test in Patients with Endometriosis before, during, and after Treatment with Danazol

Ioannis Matalliotakis, I Matalliotakis, Matalliotakis I, Dimitrios Panidis, D Panidis, Panidis D, Vlassis G, G. Vlassis, D Vavilis, Dimitrios Vavilis, Vavilis D, M Neonaki, Neonaki M, E Koumantakis, Koumantakis E
Gynecologic and obstetric investigation · 2010 · vol. 42(3) , pp. 183–186 · doi:10.1159/000291947 · PMID:8938471 · W1999434947
article OA: closed CC0 ⤵ 16 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Danazol treatment for endometriosis did not alter prolactin levels or the TRH-stimulated prolactin response, but it did significantly increase the TRH-stimulated TSH response compared to pre- and post-treatment levels.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Ten patients suffering from endometriosis were treated with danazol at a dose of 200 mg three times daily for 6 months. For evaluation of prolactin (PRL) and TSH secretion, a TRH test was carried out in the follicular phase before treatment, during the 6th month of treatment and after the reappearance of the second menses. The same test was also performed, only once, in the follicular phase of 10 normal women. The absence of a significant difference in the basal PRL levels as well as its response to the TRH test between controls and patients with endometriosis before and after danazol treatment supports the view that hyperprolactinemia should not be considered a cause of infertility in endometriotic women. Furthermore, there were no statistically significant changes in the basal levels of serum TSH during danazol treatment. On the contrary, in the TRH test, the response of serum TSH was significantly higher during danazol treatment than before or after treatment.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

MeSH descriptors

Danazol Endometriosis Estrogen Antagonists Prolactin Thyrotropin Adult Danazol Endometriosis Endometriosis Estrogen Antagonists Female Follicular Phase Follicular Phase Humans Prolactin Thyrotropin Thyrotropin-Releasing Hormone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (16)

Source provenance

europepmc
last seen: 2026-08-10T06:11:17.106188+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:11:08.331550+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK