Immunological regulation of Chinese herb Guizhi Fuling Capsule on rat endometriosis model

Ji X, Xiayun Ji, Gao J, Jian Gao, Xueting Cai, Cai X, Wuguang Lu, Lu W, Hu C, Chunping Hu, Zhigang Wang, Wang Z, Cheng X, Xiawei Cheng, Zhenhua Gu, Gu Z, Wan G, Guiping Wan, Shuangquan Zhang, Zhang S, Cao P, Peng Cao
Journal of ethnopharmacology · 2011 · vol. 134(3) , pp. 624–629 · doi:10.1016/j.jep.2011.01.003 · PMID:21220004 · W2057352931
article OA: closed CC0 ⤵ 19 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the immunological regulation of Guizhi Fuling Capsule on a rat model of endometriosis, observing its effects on immune cell activity and inflammatory markers.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Aim of the studyTo investigate the immunological regulation of Guizhi Fuling Capsule (GZFLC) on rat endometriosis.Materials and methodsTwenty-seven rats, in which endometriotic implants were induced by transplanting autologous uterine tissue to the peritoneum, were randomly divided into three groups equally: (1) the GZFLC group of low dose (480 mg/kg/day); (2) the GZFLC group of high dose (1,920 mg/kg/day); and (3) the model group(saline solution). Another 10 rats were treated as sham operation group. After rats were treated for four weeks, we examined the alterations of implants volume, the percentage of CD4(+) T lympholeukocyte, the activity of NK cell and the expression of cytokines (MCP-1 and ICAM-1) on each group.ResultsStatistical analysis showed that posttreatment volumes were significantly reduced compared with pretreatment in GZFLC groups, whereas there was no significant change in the model group. The percentage of CD4(+) T lympholeukocyte and the activity of NK cell in GZFLC groups significantly increased to the level of the sham group compared with the model. RT-PCR and immunohistochemistry showed that the endometria of the sham operation and treatment groups were similar on expression level of MCP-1 and ICAM-1.ConclusionsGZFLC plays an important role in the regression of endometriotic implants by immunological regulation in the rat model.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Drugs, Chinese Herbal Endometriosis Animals Base Sequence CD4-Positive T-Lymphocytes CD4-Positive T-Lymphocytes Chemokine CCL2 Chemokine CCL2 Disease Models, Animal DNA Primers Drugs, Chinese Herbal Endometriosis Endometriosis Female Intercellular Adhesion Molecule-1 Intercellular Adhesion Molecule-1 Killer Cells, Natural Killer Cells, Natural Rats Rats, Sprague-Dawley

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (19)

Source provenance

europepmc
last seen: 2026-07-26T06:08:39.051465+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:16:54.825375+00:00
unpaywall
last seen: 2026-06-13T06:42:57.164913+00:00
License: CC0 · commercial use OK