Cai X

BackgroundChoriocarcinoma coexisting with intrauterine pregnancy is extremely rare and necessitates early diagnosis.Case presentationA primigravida at 27+ weeks of gestation presented with a 3-day history of worsening abdominal pain. An ult…

Papillary thyroid cancer (PTC) is an endocrine malignancy with a high incidence. PTC metastasizes more frequently in children and teenagers, although survival of these patients is usually considered excellent. Still, research on regulatory …

BackgroundThe relationship between preimplantation hematological profiles and clinical pregnancy rates following frozen embryo transfer (FET) has not been thoroughly investigated.MethodsA retrospective study was conducted. Participants were…

BACKGROUND: Endometriosis affects approximately 10% of reproductive-age women, with a diagnostic delay of 7-10 years. Despite clinical heterogeneity, current rASRM staging poorly predicts treatment outcomes. Molecular subtyping may reveal b…

BACKGROUND: This study aims to use non-targeted metabolomics to analyze the metabolic characteristics of follicular fluid in patients with decreased ovarian reserve (DOR) and explore the mediating role of these metabolites in DOR and assist…

Defective endometrial decidualization is one major cause of female infertility, yet the underlying mechanisms remain elusive. Here, we identified that protein arginine methyltransferase 5 (PRMT5), which was upregulated during decidualizatio…

BACKGROUND: Numerous studies have explored the histological overlap between endometrial carcinoma and adenomyosis, yet the clinical implications of their co-occurrence remain ambiguous. This study aims to evaluate the impact of adenomyosis …

Angiogenesis is critical from early development through the progression of life-threatening diseases. In rheumatoid arthritis (RA), angiogenesis is markedly heightened and undergoes aberrant changes that exacerbate the progression of synovi…

IntroductionOvarian cancer (OC) and endometrial cancer (EC) represent two prevalent tumors within the female reproductive system, characterized by high incidence rates. Nonetheless, the clinicopathological features of synchronous endometria…

BackgroundThis study was aimed at evaluating the postoperative outcomes of vaginal natural orifice transluminal endoscopic hysterectomy (vNOTEH).MethodsThis prospective cohort study was conducted for comparing recovery outcomes, the time to…

BackgroundThe echo pattern constitutes an ultrasonic index that reflects the characteristics of the endometrium across various phases of the menstrual cycle. However, consensus of endometrial echo pattern and pregnancy outcomes is lacking i…

AbstractThe effectiveness of the GnRH antagonist protocol remains controversial due to inconsistent conclusions and inadequate subgroup analyses. The aim of this study was to provide some references for clinicians when choosing the GnRH ant…

Abstract Background The pathogenesis of adenomyosis remains incompletely understood, and no well-established biomarkers related to its inflammatory mediators have been identified. Aim This retrospective study aimed to investigate the assoc…

BackgroundImpaired decidualization is associated with recurrent implantation failure (RIF) and lysophosphatidic acid (LPA) is known to play an important role in decidua formation. However, the specific impact of LPA in endometrial deciduali…

Background: Ovarian clear cell carcinoma (OCCC) is characterized by chemoresistance and poor prognosis in advanced or recurrent cases. This study aimed to find specific prognostic markers for OCCC. Methods: We analyzed 169 OCCC patients for…

BackgroundOvarian cancer (OC) is a gynecological malignancy tumor with high recurrence and mortality rates. Programmed cell death (PCD) is an essential regulator in cancer metabolism, whose functions are still unknown in OC. Therefore, it i…

ObjectiveThis study assesses the effectiveness and safety of single-port laparoscopic myomectomy (SPLM) versus conventional laparoscopic myomectomy (CLM).MethodsWe conducted a retrospective case-control study at a university tertiary hospit…

This study aimed to evaluate the potential of capping protein (actin filament) muscle Z-line subunit β (CAPZB) messenger ribonucleic acid (mRNA) levels as a biomarker for distinguishing low-grade squamous intraepithelial lesions of the cerv…

Study questionDoes the downregulation of cell division cycle 42 (CDC42) protein in endometrial stroma lead to endometrial senescence in patients with recurrent implantation failure (RIF), and what is the potential mechanism?Summary answerCD…

A successful embryo implantation relies heavily on the receptivity of the endometrial epithelium, a process regulated by various molecular mechanisms. Evaluating endometrial receptivity in infertility patients undergoing assisted reproducti…

BACKGROUND: Endometriosis-related infertility is a common worldwide reproductive health concern. Despite ongoing research, the causes of infertility remain unclear. Evidence suggests that epigenetic regulation is crucial in reproduction. Ho…

BackgroundSuccessful embryo implantation requires the attachment of a blastocyst to the receptive endometrial epithelium, which was disturbed in the women with recurrent implantation failure (RIF). Endometrial β3-integrin was the most impor…

BackgroundsVitamin D is considered as a nutrient protecting individuals against an array of diseases based on observational studies. Such a protective effect, however, has not been demonstrated by randomized controlled trials. This study ai…

BackgroundGestational trophoblastic disease (GTD) usually affects young women of childbearing age. After treatment for GTD, 86% of women wish to achieve pregnancy. On account of the impacts of GTD and treatments as well as patient anxiety, …

BACKGROUND: Poor decidualization and abnormal autophagy conditions in the endometria of adenomyosis patients have been reported previously. However, the specific regulatory mechanism of decidualization in adenomyosis and its relationship wi…