Therapeutic Potential of Wenshen Xiaozheng Tang, a Traditional Chinese Medicine Prescription, for Treating Endometriosis

Zhenzhen Zhang, Chunping Hu, Weiwei Tang, Tao Gui, Ruyun Qian, Yuxia Xing, Yuxin Xing, Peng Cao, Guiping Wan
Reproductive sciences (Thousand Oaks, Calif.) · 2013 · vol. 20(10) , pp. 1215–1223 · doi:10.1177/1933719113483008 · PMID:23536573 · W2157968761
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Wenshen Xiaozheng Tang (WXT) treatment significantly decreased endometriosis lesion size and inflammatory markers while downregulating invasion-related genes in a rat model.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study evaluated the effects of Wenshen Xiaozheng Tang (WXT), a traditional Chinese medicine prescription, on endometriosis development in Sprague-Dawley rats with induced endometriotic implants. Rats received low-dose or high-dose WXT (8.57 or 17.14 g/kg/day) or control solvent for 4 weeks, and lesion size plus inflammatory and invasion-related markers were measured. WXT significantly reduced mean lesion size and lowered peritoneal fluid and serum levels of tumor necrosis factor α and interleukin 1β, alongside downregulation of COX-2, MMP-9, PAI-1, and ICAM-1 mRNA with upregulation of TIMP-1 mRNA in lesions. This paper does not include a stated limitation in the provided text beyond being an animal-model study, and the results reflect a rat experimental setup rather than human outcomes. This paper is centrally about endometriosis — it tests the therapeutic potential of Wenshen Xiaozheng Tang in a rat endometriosis model by examining inflammatory cytokines and invasion-related gene expression.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Drugs, Chinese Herbal Endometriosis Medicine, Chinese Traditional Animals Drugs, Chinese Herbal Drugs, Chinese Herbal Endometriosis Endometriosis Female Medicine, Chinese Traditional Rats Rats, Sprague-Dawley Treatment Outcome

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