Fibrinolytic factors in endometriotic tissue, endometrium, peritoneal fluid, and plasma from women with endometriosis and in endometrium and peritoneal fluid from healthy women

Christine Bruse, C Bruse, Bruse C, Bergqvist A, Agneta Bergqvist, A Bergqvist, Carlström K, K Carlström, Kjell Carlström, Aino Fianu-Jonasson, A Fianu-Jonasson, Fianu-Jonasson A, Lecander I, I Lecander, Ingegerd Lecander, B Astedt, Birger Åstedt, Astedt B
Fertility and Sterility · 1998 · vol. 70(5) , pp. 821–826 · doi:10.1016/s0015-0282(98)00285-4 · PMID:9806560 · W2056485200
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Researchers analyzed fibrinolytic factors in endometriotic tissue, endometrium, peritoneal fluid, and plasma from women with endometriosis compared to endometrium and peritoneal fluid from healthy women.

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Abstract

ObjectiveTo determine whether there is a difference in fibrinolytic compounds in endometriotic tissue, endometrium, peritoneal fluid (PF), and plasma from women with endometriosis and in endometrium and PF from healthy women.DesignProspective study.SettingTwo university clinics.Patient(s)Regularly menstruating women with and without endometriosis.Intervention(s)Tissue samples, PF, and blood were collected at surgery performed for clinical reasons.Main outcome measure(s)The antigen concentrations of plasminogen activators and plasminogen activator inhibitors (PAls) in tissue homogenates, PF, and plasma were assayed by ELISA.Result(s)The concentrations of urokinase plasminogen activator (u-PA) and PAI-1 were higher in endometrium from women with endometriosis than in endometrium from controls and even higher in endometriotic tissue than in endometrium from both groups. In PF, the concentration of PAI-2 was higher in women with endometriosis than in controls.Conclusion(s)The high concentrations of u-PA and PAI-1 in endometrium from women with endometriosis might facilitate implantation of endometrial cells and the high concentration in endometriotic tissue might contribute to their invasive growth. The inflammatory reaction may contribute to the high concentration of PAI-2.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endometrium Fibrinolysis Adult Ascitic Fluid Case-Control Studies Endometriosis Endometriosis Endometrium Female Fibrinolysis Humans Middle Aged Prospective Studies Reference Values

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