Fibrin clot properties among women with endometriosis and the impact of ovarian stimulation

Magdalena Piróg, Olga Kacalska-Janssen, Olga Kacalska‐Janssen, Kacalska-Janssen O, Jach R, Robert Jach, Michał Ząbczyk, Joanna Natorska, Natorska J
Reproductive biomedicine online · 2021 · vol. 43(1) , pp. 81–90 · doi:10.1016/j.rbmo.2021.03.008 · PMID:34001444 · W3138700631
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-11 ⓘ

This study investigated fibrin clot properties in women with endometriosis, examining how ovarian stimulation affects these properties.

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This study examined fibrin clot properties in women with endometriosis and assessed how ovarian stimulation affects these clot characteristics, using an observational design (specific methods such as assays and sampling details are not provided in the available text). The key result reported is that ovarian stimulation was associated with measurable changes in fibrin clot properties among women with endometriosis. A major limitation explicitly evident from the provided information is that the full methodological details and statistical results are not included here, preventing evaluation of effect sizes and robustness. This paper is centrally about endometriosis — it focuses on how endometriosis and ovarian stimulation influence fibrin clot properties.

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Abstract

Research questionIs there a difference in fibrin clot phenotype in women with endometriosis before and after ovarian stimulation?DesignProspective study including 73 infertile women in two age-matched groups: (i) with confirmed endometriosis (n = 29); (ii) without endometriosis (n = 44). Assessments of plasma fibrin clot permeability (Ks), efficiency of fibrinolysis using clot lysis time (CLT), along with thrombin generation (prothrombin fragments 1+2 [F1+2] and endogenous thrombin potential [ETP]) and fibrinolysis inhibitors were performed together with clinical pregnancy rate.ResultsEndometriosis was associated with increased thrombin generation, reflected by both higher F1+2 (+96.1%, P = 0.005) and ETP (+14.2%, P = 0.014) along with unfavourably altered fibrin clot properties represented by lower Ks (-31%, P < 0.001) and prolonged CLT (+13.5%, P = 0.02), compared with the non-endometriosis group. Moreover, women with endometriosis had higher plasminogen activator inhibitor-1 (PAI-1; +272%, P = 0.004) concentrations and alpha-2-antiplasmin activity (+39.9%, P < 0.001) in contrast to the other group. Ovarian stimulation led to reduction in F1+2 (-48.1%, P < 0.001), improvement of fibrin clot phenotype reflected by higher Ks (+25.9%, P < 0.001) and shortened CLT (-11.9%, P < 0.001), along with lower PAI-1 (-54%, P = 0.016) compared with the baseline in women with endometriosis.ConclusionsEndometriosis is associated with the prothrombotic fibrin clot phenotype and increased thrombin generation. Ovarian stimulation favourably alters fibrin clot properties and leads to comparable pregnancy outcomes to those in women without endometriosis.
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Simple view Full metadata view Authors Statistics Fibrin clot properties among women with endometriosis and the impact of ovarian stimulation Journal Reproductive BioMedicine Online 100 Author Piróg Magdalena Kacalska-Janssen Olga Jach Robert Ząbczyk Michał Natorska Joanna Volume 43 Number 1 Pages 81-90 ISSN 1472-6483 eISSN 1472-6491 Access date 2022-02-01 Language English Journal language English Affiliation Wydział Lekarski : Klinika Endokrynologii GinekologicznejWydział Lekarski : Instytut Kardiologii Scopus© citations 12 | cris.lastimport.wos | 2024-04-10T01:56:20Z | | | dc.affiliation | Wydział Lekarski : Klinika Endokrynologii Ginekologicznej | pl | | dc.affiliation | Wydział Lekarski : Instytut Kardiologii | pl | | dc.cm.date | 2021-09-09 | | | dc.cm.id | 104649 | | | dc.cm.idOmega | UJCMcca49db716db4c45b73ba159676aed79 | pl | | dc.contributor.author | Piróg, Magdalena | pl | | dc.contributor.author | Kacalska-Janssen, Olga - 173921 | pl | | dc.contributor.author | Jach, Robert - 129777 | pl | | dc.contributor.author | Ząbczyk, Michał - 137370 | pl | | dc.contributor.author | Natorska, Joanna - 130892 | pl | | dc.date.accession | 2022-02-01 | pl | | dc.date.accessioned | 2021-09-09T10:13:38Z | | | dc.date.available | 2021-09-09T10:13:38Z | | | dc.date.issued | 2021 | pl | | dc.description.number | 1 | pl | | dc.description.physical | 81-90 | pl | | dc.description.points | 100 | | | dc.description.volume | 43 | pl | | dc.identifier.doi | 10.1016/j.rbmo.2021.03.008 | pl | | dc.identifier.eissn | 1472-6491 | pl | | dc.identifier.issn | 1472-6483 | pl | | dc.identifier.project | ROD UJ / O | pl | | dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/278342 | | | dc.language | eng | pl | | dc.language.container | eng | pl | | dc.pbn.affiliation | Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne | | | dc.rights | Dodaję tylko opis bibliograficzny | * | | dc.rights.licence | Bez licencji otwartego dostępu | | | dc.source.integrator | false | | | dc.subtype | Article | pl | | dc.title | Fibrin clot properties among women with endometriosis and the impact of ovarian stimulation | pl | | dc.title.journal | Reproductive BioMedicine Online | pl | | dc.type | JournalArticle | pl | | dspace.entity.type | Publication | cris.lastimport.wos 2024-04-10T01:56:20Z dc.affiliationpl Wydział Lekarski : Klinika Endokrynologii Ginekologicznej dc.affiliationpl Wydział Lekarski : Instytut Kardiologii dc.cm.date 2021-09-09 dc.cm.id 104649 dc.cm.idOmegapl UJCMcca49db716db4c45b73ba159676aed79 dc.contributor.authorpl Piróg, Magdalena dc.contributor.authorpl Kacalska-Janssen, Olga - 173921 dc.contributor.authorpl Jach, Robert - 129777 dc.contributor.authorpl Ząbczyk, Michał - 137370 dc.contributor.authorpl Natorska, Joanna - 130892 dc.date.accessionpl 2022-02-01 dc.date.accessioned 2021-09-09T10:13:38Z dc.date.available 2021-09-09T10:13:38Z dc.date.issuedpl 2021 dc.description.numberpl 1 dc.description.physicalpl 81-90 dc.description.points 100 dc.description.volumepl 43 dc.identifier.doipl 10.1016/j.rbmo.2021.03.008 dc.identifier.eissnpl 1472-6491 dc.identifier.issnpl 1472-6483 dc.identifier.projectpl ROD UJ / O dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/278342 dc.languagepl eng dc.language.containerpl eng dc.pbn.affiliation Dziedzina nauk medycznych i nauk o zdrowiu : nauki medyczne dc.rights* Dodaję tylko opis bibliograficzny dc.rights.licence Bez licencji otwartego dostępu dc.source.integrator false dc.subtypepl Article dc.titlepl Fibrin clot properties among women with endometriosis and the impact of ovarian stimulation dc.title.journalpl Reproductive BioMedicine Online dc.typepl JournalArticle dspace.entity.type Publication Affiliations Wydział Lekarski Piróg, Magdalena Kacalska-Janssen, Olga Jach, Robert Ząbczyk, Michał Natorska, Joanna * The migration of download and view statistics prior to the date of April 8, 2024 is in progress. Views 17 Views per month Views per city Hong Kong 4 Ashburn 3 Wroclaw 2 Dublin 1 No access No Thumbnail Available

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fibrin Clot Lysis Time Ovulation Induction Thrombosis Adult Endometriosis Endometriosis Female Fibrin Fibrin Humans Prospective Studies

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