Plasminogen activator inhibitor-1 4G/5G polymorphism in infertile women with and without endometriosis

Rubens P Gonçalves-Filho, Rubens Paulo Gonçalves-Filho, Gonçalves-Filho RP, Ariel Brandes, A. Brandes, Brandes A, Denise M Christofolini, Denise Maria Christofolini, Lerner TG, Tatiana G Lerner, Tatiana Goberstein Lerner, Bianca Bianco, Caio P Barbosa, Caio Parente Barbosa
Acta obstetricia et gynecologica Scandinavica · 2011 · vol. 90(5) , pp. 473–477 · doi:10.1111/j.1600-0412.2011.01086.x · PMID:21306344 · W1597239044
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This study investigated PAI-1 4G/5G genotypes in infertile women with and without endometriosis, finding an association between this polymorphism and endometriosis-associated infertility in Brazilian women.

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Abstract

OBJECTIVE: To evaluate PAI-1 genotypes in a group of infertile women with or without endometriosis and control subjects. DESIGN: Case-control study. SETTING: Human Reproduction Center of Medicina do ABC Faculty. POPULATION: One hundred and forty infertile women with endometriosis, 64 women with idiopathic infertility and 148 fertile women as control subjects. METHODS: The PAI-1 4G/5G polymorphism was identified by restriction fragment length polymorphism-polymerase chain reaction. MAIN OUTCOME MEASURES: Genotype distribution and allele frequency of the 4G/5G polymorphism of the PAI-1 gene. RESULTS: The frequencies of genotypes 4G/4G, 4G/5G and 5G/5G of the PAI-1 gene in the infertile women with endometriosis were 38.6, 37.1 and 24.3%, respectively, and in the control group 24.3, 33.8 and 41.9%, respectively (p=0.003). When the infertile women with endometriosis were divided according to their endometriosis stage, genotypes 4G/4G, 4G/5G and 5G/5G were identified, respectively, in 36.7, 32.9 and 30.4% of the patients with minimal/mild endometriosis (p=0.102) and in 41.0, 42.6 and 16.4% of the patients with moderate/severe endometriosis (p=0.001); in the women with idiopathic infertility, these genotypes were found at a frequency of 29.7, 34.3 and 36%, respectively (p=0.637). CONCLUSION: The data suggest that, in Brazilian women, the PAI-1 4G/5G polymorphism may be associated with a risk of endometriosis-associated infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Infertility Plasminogen Activator Inhibitor 1 Polymorphism, Genetic Adult Brazil Case-Control Studies Endometriosis Female Gene Frequency Genotype Humans Infertility Infertility Infertility Odds Ratio Plasminogen Activator Inhibitor 1 Polymerase Chain Reaction Polymorphism, Restriction Fragment Length

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