Plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism and endometriosis. Influence of PAI-1 polymorphism on PAI-1 antigen and mRNA expression

Luis Ramón, Ramón LA, Luis A Ramón, Juan Gilabert-Estellés, Juan Gilabert–Estellés, Cosín R, Raul Cosín, R. Cosín, Gilabert J, Juan Gilabert, Francisco España, Castelló R, Remedios Castelló, Chirivella M, Melitina Chirivella, Romeu A, A Romeu, Alberto Romeu, Amparo Estellés, Estellés A
Thrombosis research · 2008 · vol. 122(6) , pp. 854–860 · doi:10.1016/j.thromres.2008.02.010 · PMID:18423526 · W1999259515
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This study investigated the association between the PAI-1 4G/5G polymorphism and endometriosis, and its influence on PAI-1 antigen and mRNA expression levels.

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Abstract

IntroductionEndometriosis is a benign gynecologic disease with a high prevalence. It is a multifactorial and polygenic entity in which the fibrinolytic system may be implicated. The objective of this study was to evaluate the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism in a group of women with and without endometriosis and to analyze the influence of this polymorphism in PAI-1 expression in endometrial tissue and peritoneal fluid.Material and methodsIn 389 women (170 patients with endometriosis and 219 controls) PAI-1 4G/5G polymorphism was determined by PCR amplification using allele-specific primers. Quantitative real-time RT-PCR assay was used to quantify PAI-1 mRNA and PAI-1 antigen (ag) levels were quantified by ELISA.ResultsThe genotype and allele frequencies of PAI-1 4G/5G polymorphism did not differ significantly between patients and controls. Control women with the 4G/4G genotype had higher endometrial PAI-1ag (P=0.026) and mRNA (P=0.014) levels than those with the 5G/5G genotype. Control carrying the 4G/4G genotype tended to have higher peritoneal fluid PAI-1ag levels than those carrying the 5G/5G genotype. Moreover, PAI-1ag levels in peritoneal fluid were higher in patients than in controls (P=0.003).ConclusionsThe PAI-1 genotype distribution was similar in patients and controls. PAI-1 levels in endometrial tissue and peritoneal fluid seem to be associated with PAI-1 4G/5G polymorphism in controls. The increased PAI-1ag levels observed in peritoneal fluid from patients could contribute to increase the peritoneal adhesions observed in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Plasminogen Activator Inhibitor 1 Polymorphism, Genetic RNA, Messenger Adolescent Adult Ascitic Fluid Ascitic Fluid Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans Middle Aged Plasminogen Activator Inhibitor 1 Plasminogen Activator Inhibitor 1 RNA, Messenger

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