Genetic Variants in Fibrinolytic System-Related Genes in Infertile Women With and Without Endometriosis

A. Brandes, Ariel Brandes, Brandes A, Denise M Christofolini, Denise Maria Christofolini, Cavalheiro CM, Camila M Cavalheiro, Vilarino FL, Fabia Lima Vilariño, Fabia L Vilarino, André GM, Gustavo Mendonça André, Gustavo M André, Bianca Bianco, Caio P Barbosa, Caio Parente Barbosa
Genetic testing and molecular biomarkers · 2011 · vol. 16(1) , pp. 54–57 · doi:10.1089/gtmb.2011.0112 · PMID:21819230 · W2093113935
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This study found no association between urokinase-type plasminogen activator and thrombin-activatable fibrinolysis inhibitor gene polymorphisms and endometriosis-related or idiopathic infertility in the Brazilian population.

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Abstract

AIMS: The aim of this study was to evaluate urokinase-type plasminogen activator gene (uPA) and thrombin-activatable fibrinolysis inhibitor gene (TAFI) genotypes in a group of infertile women with and/or without endometriosis and controls. METHODS: A case-control study comprising 180 infertile women with endometriosis, 68 women with idiopathic infertility, and 152 fertile women as controls was carried out. Detection of uPA (C422T/rs2227564) and TAFI (G438A/rs2146881) polymorphisms was performed by TaqMan polymerase chain reaction. The results were statistically analyzed and a p-value of <0.05 was considered significant. RESULTS: We found no association among both uPA or TAFI polymorphisms and endometriosis-related infertility (p=0.920 and p=0.356, respectively) or idiopathic infertility (p=0.502 and p=0.392, respectively) comparing to controls, even considering minimal/mild and moderate/severe endometriosis separately. Both uPA and TAFI polymorphisms were in Hardy-Weinberg equilibrium for all studied groups. The combinatory analysis of both uPA and TAFI polymorphisms to endometriosis-related infertility, idiopathic infertility, and control group showed no statistical difference to any combination. CONCLUSION: The data suggest that, in the Brazilian population, genetic variations in both uPA and TAFI were not relevant to endometriosis and/or infertility.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Fibrinolysis Genetic Variation Genetic Variation Infertility, Female Uterine Diseases Adult Brazil Carboxypeptidase B2 Carboxypeptidase B2 Case-Control Studies Endometriosis Endometriosis Female Fibrinolysis Gene Frequency Genetic Predisposition to Disease Genotype Humans Infertility, Female

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