In situ localization of mRNA for the fibrinolytic factors uPA, PAI-1 and uPAR in endometriotic and endometrial tissue

C Bruse, Christine Bruse, D Radu, A Bergqvist
Molecular human reproduction · 2004 · vol. 10(3) , pp. 159–166 · doi:10.1093/molehr/gah033 · PMID:14981142 · W2112903545
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This study localized mRNA for uPA, PAI-1, and uPAR in endometriotic and endometrial tissues, finding upregulation of these fibrinolytic factors in endometriotic lesions and endometrium from women with endometriosis.

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Abstract

Endometriotic tissue grows invasively. The plasminogen-activating system is suggested to participate in degradation of extracellular matrix (ECM) and modulation of cell adhesion and migration. We have previously demonstrated elevated levels of the fibrinolytic factors urokinase plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in endometriotic tissue and endometrium from women with endometriosis. The aim of the present study was to localize the uPA, PAI-1 and urokinase plasminogen activator receptor (uPAR) mRNA in endometriotic tissue and in endometrium both from women with and without endometriosis. With in situ hybridization, we found that uPA mRNA seems to be up-regulated in endometriotic glands and endometrial stroma as well as PAI-1 mRNA in endometriotic and endometrial stroma from women with endometriosis. uPAR mRNA likewise appears to be up-regulated in both glands and stroma in endometriotic tissue and in endometrial glands from patients compared to endometrial glands and stroma from healthy women. These differences might be important for menstrual shedding and adherence of endometrial fragments to peritoneal lining in women developing endometriosis and for the invasive growth of endometriotic tissue.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Plasminogen Activator Inhibitor 1 Receptors, Cell Surface Urokinase-Type Plasminogen Activator Endometriosis Endometrium Female Humans In Situ Hybridization Menstrual Cycle Menstrual Cycle Menstrual Cycle Plasminogen Activator Inhibitor 1 Plasminogen Activator Inhibitor 1 Receptors, Cell Surface Receptors, Cell Surface Receptors, Urokinase Plasminogen Activator RNA, Messenger RNA, Messenger

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