Impact of Continuous Estroprogestin Treatment on Circulating Microparticle Levels in Deep Endometriosis Patients

P. Carrillo Torres, Pilar Carrillo Torres, Maria Ángeles Martínez‐Zamora, María Ángeles Martínez-Zamora, Dolors Tàssies, Helena Castillo‐Ecija, Helena Castillo, Meritxell Gracia, Meritxell Gràcia, Georgina Feixas, Joan Carles Reverter, Francisco Carmona
International journal of molecular sciences · 2023 · vol. 24(14) , pp. 11802 · doi:10.3390/ijms241411802 · PMID:37511561 · W4385161805
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Continuous estroprogestin treatment reduced circulating microparticle levels in deep endometriosis patients, while increasing microparticles expressing tissue factor compared to untreated patients.

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Abstract

There has been increasing interest in the study of new pathogenic mechanisms in endometriosis (END), including the coagulation/fibrinolysis system and its link with inflammation and tissue remodeling. It has been suggested that END patients, especially with deep-infiltrating (DE) forms, could present a hypercoagulable state revealing higher levels of proinflammatory and procoagulant markers, such as total circulating microparticles (cMPs) and cMP-TF (tissue factor), released by cells in response to damage, activation, or apoptosis. However, no previous study has assessed the effect of END hormonal treatments on cMP and cMP-TF levels. Therefore, the aim of this study was to evaluate the impact of these treatments on cMP and cMP-TF levels in DE patients. Three groups were compared: DE patients receiving a continuous combined oral contraceptive regimen (CCOCR) (n = 41), DE patients without CCOCR (n = 45), and a control group (n = 43). cMP and cMP-TF levels were evaluated in platelet-free plasma. A significant decrease in the total cMP levels was found in the DE group with CCOCR versus the group without CCOCR, reflecting a higher chronic inflammatory status in DE patients that decreased with the treatment. cMP-TF levels were higher in DE patients receiving CCOCR versus those not receiving CCOCR, suggesting that treatments containing estrogens play a predominant role in suppressing the inhibitory pathway of TF.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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