Research Progress on the Correlation of Inflammation, Coagulation Markers, and CA125 with Endometriosis

炎症、凝血指标及CA125与子宫内膜异位症的相关性研究进展 Research Progress on the Correlation of Inflammation, Coagulation Markers, and CA125 with Endometriosis Research Progress on the Correlation of Inflammation, Coagulation Markers, and CA125 with Endometriosis DOI: 10.12677/acm.2024.14123193, PDF, 被引量 作者: 王 恬, 向慧珍*：吉首大学医学院，湖南 吉首；吉首大学第四临床学院，湖南 怀化；黄大元：吉首大学医学院，湖南 吉首 关键词: 子宫内膜异位症；炎症；凝血；CA125；Endometriosis； Inflammation； Coagulation； CA125 作者: 王 恬, 向慧珍*：吉首大学医学院，湖南 吉首；吉首大学第四临床学院，湖南 怀化；黄大元：吉首大学医学院，湖南 吉首 关键词: 子宫内膜异位症；炎症；凝血；CA125；Endometriosis； Inflammation； Coagulation； CA125 摘要: 子宫内膜异位症(Endometriosis, EMs)，简称内异症，指子宫内膜细胞(含腺体和间质)在子宫外区域的生长。EMs最常见的临床症状包括慢性盆腔痛、深部性交痛及不孕，影响了大约10%育龄期妇女，部分EMs患者早期无明显临床症状，因此，EMs的真正患病率尚不能确定，且EMS的临床表现与盆腔恶性肿瘤相似，早期难以通过影像学诊断发现，缺乏可靠、安全的无创诊断及监测病情变化的敏感指标。故寻求一种特异度、灵敏度均较高、无创伤的血清指标应用于EMS早期诊断是当前临床高度关注的内容，本文旨在探讨炎症、凝血、CA125等因素与子宫内膜异位症发病机制的相关性，深化对该疾病病理生理过程的理解，并剖析炎症指标、凝血指标及CA125水平与疾病进展的关联及其诊断意义，为未来临床研究与个性化治疗策略的制定提供理论支撑。 Abstract: Endometriosis (EMs), also known as endometriosis, refers to the growth of endometrial cells (including glands and stroma) in extrauterine regions. The most common clinical symptoms of EMs include chronic pelvic pain, deep dyspareunia, and infertility, affecting approximately 10% of women of reproductive age. Some patients with EMs have no obvious clinical symptoms in the early stages, so the true prevalence of EMs is not yet fully determined. Moreover, the clinical manifestations of EMS are similar to those of pelvic malignant tumors, making early detection through imaging difficult, and there are currently no reliable, safe non-invasive diagnostic and sensitive markers for monitoring disease progression. Therefore, there is a high clinical focus on seeking a serum marker with both high specificity and sensitivity for the early diagnosis of EMS. This article aims to explore the correlation of factors such as inflammation, coagulation, and CA125 with the pathogenesis of endometriosis, deepen the understanding of the pathophysiological processes of the disease, and analyze the association of inflammatory markers, coagulation markers, and CA125 levels with disease progression and their diagnostic significance, providing theoretical support for future clinical research and the formulation of personalized treatment strategies. 文章引用：王恬, 黄大元, 向慧珍. 炎症、凝血指标及CA125与子宫内膜异位症的相关性研究进展[J]. 临床医学进展, 2024, 14(12): 1112-1119. https://doi.org/10.12677/acm.2024.14123193 | [1] | 中国医师协会妇产科医师分会, 中华医学会妇产科学分会子宫内膜异位症协作组. 子宫内膜异位症诊治指南(第三版) [J]. 中华妇产科杂志, 2021, 56(12): 812-824. | | [2] | 沈雪, 汪沙, 段华. 第四届全球子宫内膜异位症及子宫疾病协会年会侧记[J]. 中华妇产科杂志, 2018, 53(9): 654-656. | | [3] | Bg, P., Ee, L., Di, L., et al. (2018) Pathogenesis of Endometriosis: Interaction between Endocrine and Inflammatory Path-Ways. 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