Red blood cell indices as an effective marker for the existence and severity of endometriosis (STROBE)

Hye Yon Cho, Hye-Yon Cho, Sung Taek Park, Sung-Taek Park, Sung-Ho Park, Sung‐Ho Park
Medicine · 2022 · vol. 101(42) , pp. e31157 · doi:10.1097/md.0000000000031157 · PMID:36281126 · W4307381269
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Lower red blood cell indices and higher neutrophil-to-lymphocyte ratio were significantly associated with more severe endometriosis stages, identifying several as independent risk factors.

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Abstract

To evaluate the association between red blood cell (RBC) indices (mean corpuscular volume [MCV], mean corpuscular hemoglobin [MCH], MCH concentration [MCHC], red cell distribution width [RDW], hemoglobin [Hb], hematocrit [Hct], and neutrophil-to-lymphocyte ratio [NLR]) and the severity of endometriosis. Data were obtained from the medical records of 200 patients with endometriosis (stage I/II and stage III/IV groups), and 100 patients with benign ovarian tumors (control group), treated between September 2011 and April 2021. The mean Hb and Hct were significantly lower in the stage III/IV group compared to those in the control and stage I/II group (P = .015 and P = .004, respectively). The mean MCV, MCH, and Hb at postoperative day (POD)#1 were significantly lower in the stage III/IV group compared to those in the control and stage I/II group (P = .007, P = .032, and P < .0001, respectively). In addition, NLR at POD#1 was significantly higher in stage III/IV group compared to that in the control and stage I/II group. Multivariate analysis revealed that younger age (≤38 years old), lower preoperative MCV (≤88.5 fL), lower POD#1 Hb (2.5) were independent risk factors of stage III/IV endometriosis. Lower levels of RBC indices, including preoperative MCV and postoperative Hb, and higher postoperative NLR were significantly associated with the severity of endometriosis, which is potentially derived from a dysregulation in iron metabolism and inflammation.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Erythrocyte Indices Erythrocyte Indices Erythrocyte Indices Erythrocyte Indices Erythrocyte Indices Erythrocyte Indices Erythrocyte Indices Adult Adult Adult Adult Adult

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