Medicine

Identification of appropriate biomarkers is of great clinical significance for early diagnosis of endometriosis (EMs). This study aimed to comprehensively analyze the association between EMs and blood and urine biomarkers (BUB). Candidate E…

To explore the genetic associations between 91 types of blood cells (BCs) and endometriosis (EMs), providing references for the treatment of EMs. Forward Mendelian randomization (MR) analysis was conducted with BC-related single nucleotide …

The potential bidirectional causal relationship between endometriosis and serum 25-hydroxyvitamin D has been previously investigated. Nevertheless, the results could be impacted by confounding factors and reverse causality because of the na…

Endometriosis and menorrhagia are prevalent gynecological conditions with overlapping symptoms, yet comparative data from Middle Eastern populations remain scarce. We aimed to comprehensively characterize demographic and hematological diffe…

Endometriosis (EMS) is a chronic condition primarily characterized by pain and infertility, significantly affecting the physical, mental, and emotional well-being of patients. The primary goal of EMS treatment is to improve patients' qualit…

This study aimed to construct and validate a nomogram for predicting natural pregnancy after hysteroscopy and laparoscopy in patients with tubal infertility and pelvic endometriosis, providing a basis for precise clinical evaluation and per…

This study aims to investigate the differences in response to dienogest (DNG) therapy among patients with 3 different phenotypes of endometriosis: ovarian endometrioma (OMA), superficial peritoneal endometriosis (SUP), and deep infiltrating…

Endometriosis is a chronic inflammatory disease that can cause many problems such as dipmenorrhea, dyspareunia, pelvic pain, and infertility. The aim of this study was to investigate the clinical, demographic, and laboratory characteristics…

Endocrine disrupting chemicals (EDCs) have been associated with disorders affecting female reproductive health, although the precise causal connections and underlying pathways between these substances and such disorders remain incompletely …

BACKGROUND: Endometrial carcinoma arising from adenomyosis (EC-AIA) is remarkably uncommon, and its underlying molecular mechanisms are not yet fully elucidated. This knowledge gap is particularly significant given that most reported EC-AIA…

This study aims to elucidate the molecular mechanisms underlying luteolin's therapeutic effects on polycystic ovary syndrome (PCOS) and endometriosis (EM), thereby providing a theoretical foundation for developing novel treatment strategies…

Dyslipidaemia is related to endometriosis, but it is not known which lipid component is most relevant, and whether the observed correlation reflects the causal relationship. The relationship between triglycerides (TG) and endometriosis is s…

The independent causal effects of interrelated lifestyle behaviors and psychological states on women's gynecologic and obstetric health remain incompletely understood. We conducted a comprehensive Mendelian randomization (MR) study to disen…

To explore the material basis and network mechanism of the Guizhi Fuling pills in the treatment of endometriosis and endometrial polyps based on network pharmacology and machine learning. The effective constituents and targets of the Guizhi…

This study aims to investigate the effect of endometriosis (EMs) on fertility and to assess the causal relationship between EMs and fertility using two-sample Mendelian randomization (MR). We conducted an observational study using data from…

This study aims to explore the application value of stromal cell-derived factor (CXCL12), vascular endothelial growth factor (VEGF) and carbohydrate antigen 125 (CA125) in the diagnosis, staging, and clinical manifestations of endometriosis…

BACKGROUND: This study evaluated the efficacy of acupuncture as a monotherapy for managing endometriosis-related pain (ERP) compared to non-acupuncture interventions. METHODS: We systematically searched PubMed, EMBASE, Cochrane Library, CNK…

At present, there is unclear on the risk factors of recurrence after myomectomy. In this study, we hope to provide reference for the choice of treatment for patients with uterine fibroids and provide basis for the subsequent prediction of r…

Reproductive endocrine diseases (REDs), including polycystic ovary syndrome, endometriosis, and female infertility, are prevalent reproductive disorders that affect a significant number of women worldwide. Recent research has indicated that…

Endometriosis is a prevalent gynecological disorder, with its pathogenesis potentially linked to oxidative stress. Carotenoids, as natural antioxidants, may play a role in its prevention. This study aimed to investigate the association betw…

Endometriosis (EMs) and depression are both common conditions that have a significant negative impact on quality of life. However, it is still unclear about the relationship between them. The study was designed to investigate the phenotypic…

Endometriosis is a prevalent reproductive disorder that affects a significant number of women globally. Cathepsins, which are lysosomal cysteine proteases, contribute to several physiological and pathological processes, including the attach…

Evidence have indicated a correlation between sleep disorders and endometriosis, but the causal relationship remains uncertain. This study utilized Mendelian randomization (MR) approach to investigate the causal associations between sleep d…

Endometriosis (EMS) is a complex gynecological disorder whose pathogenesis remains poorly understood, with lipid metabolism, immune regulation, and inflammation likely playing pivotal roles. This Mendelian randomization study investigates c…

RATIONALE: Benign gynecological disorders causing abnormal uterine bleeding (AUB), such as adenomyosis, may trigger recurrent thrombosis similar to Trousseau syndrome. Trousseau syndrome is characterized by recurrent thrombotic events in pa…