Associations between atherogenic index of plasma and endometriosis: The National Health and Nutrition Examination Survey 1999 to 2006

Yanan Ren, Ying Jin, Xinjun Li, Shaoqing Wang, Jing Zhao, Luyang Su
In: Medicine · 2026 · vol. 105(26) , pp. e49486 · doi:10.1097/md.0000000000049486 · W7166039857
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Abstract

It has been proved that lipids have an effect on endometriosis, and the plasma atherosclerosis index (AIP), as a new lipid index, has not been proved to be correlative to endometriosis. The National Health and Nutrition Examination Survey from 1999 to 2006 covered 2405 female. AIP (log10 (triglyceride/high-density lipoprotein cholesterol)) was employed to evaluate the danger of hyperlipidemia. Moreover, the connection between AIP and endometriosis can be further studied by using multivariate logistic regression, restricted cubic spline and subgroup analysis. Totally 2405 female were covered, of whom 182 (7.57%) had endometriosis and 2223 (92.43%) did not have endometriosis (named control). The AIP level in the endometriosis group (0.37) was visibly exceed that in the non-endometriosis group (0.26), and the imparity was statistically meaningful( P < .0001), even when sensitivity analysis was performed, the imparity retained the same. Overall, there was a significant active connection between the AIP and endometriosis (per 1-unit increment in the AIP: OR = 2.624; 95% CI 1.479, 4.657). The consequences of subgroup analysis demonstrated that there was no meaningful interaction between AIP and concrete subgroups (all interaction P < .05). Restricted cubic spline analysisprovide evidence of statistically significant linearity between AIP and endometriosis prevalence. AIP is actively connection with endometriosis in US female. Therefore, by using AIP as a new lipid market indicator, we are expected to offer new ideas and insights into the prevention and treatment of endometriosis.“ To further confirm our works, we need larger cohort researches to support the consequences of this research.

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