Macrophage‐derived insulin‐like growth factor‐1 is a key neurotrophic and nerve‐sensitizing factor in pain associated with endometriosis

Rachel Forster, Alexandra Sarginson, Atanaska Velichkova, Atanaska N. Velichkova, Chloe Hogg, Ashley Dorning, Andrew W Horne, Philippa T K Saunders, Erin Greaves
FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019 · vol. 33(10) , pp. 11210–11222 · doi:10.1096/fj.201900797r · PMID:31291762 · W2956266291
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Macrophage-derived insulin-like growth factor-1 (IGF-1) promotes neurogenesis and nerve sensitization, reversing pain behaviors in endometriosis models.

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Abstract

ABSTRACT Endometriosis is a common incurable inflammatory disorder that is associated with debilitating pelvic pain in women. Macrophages are central to the pathophysiology of endometriosis: they dictate the growth and vascularization of endometriosis lesions and more recently have been shown to promote lesion innervation. The aim of this study was to determine the mechanistic role of macrophages in producing pain associated with endometriosis. Herein, we show that macrophage depletion in a mouse model of endometriosis can reverse abnormal changes in pain behavior. We identified that disease‐modified macrophages exhibit increased expression of IGF‐1 in an in vitro model of endometriosis‐associated macrophages and confirmed expression by lesion‐resident macrophages in mice and women. Concentrations of IGF‐1 were elevated in peritoneal fluid from women with endometriosis and positively correlate with their pain scores. Mechanistically, we demonstrate that macrophage‐derived IGF‐1 promotes sprouting neurogenesis and nerve sensitization in vitro . Finally, we show that the Igf‐1 receptor inhibitor linsitinib reverses the pain behavior observed in mice with endometriosis. Our data support a role for macrophage‐derived IGF‐1 as a key neurotrophic and sensitizing factor in endometriosis, and we propose that therapies that modify macrophage phenotype may be attractive therapeutic options for the treatment of women with endometriosis‐associated pain.—Forster, R., Sarginson, A., Velichkova, A., Hogg, C., Doming, A., Home, A. W., Saunders, P. T. K., Greaves, E. Macrophage‐derived insulin‐like growth factor‐1 is a key neurotrophic and nerve‐sensitizing factor in pain associated with endometriosis. FASEB J. 33, 11210–11222 (2019). www.fasebj.org

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Insulin-Like Growth Factor I Macrophages Pain Animals Cell Line Endometriosis Endometriosis Female Humans Insulin-Like Growth Factor I Macrophages Macrophages Mice Mice, Inbred C57BL Nerve Fibers Nerve Fibers Nerve Fibers Neurogenesis Neurogenesis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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