Insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis

Kim JG, J G Kim, Jung Gu Kim, Suh CS, C S Suh, Chang Seok Suh, Kim SH, Seok Hyun Kim, S H Kim, Young Min Choi, Choi YM, Y M Choi, Shin Yong Moon, S Y Moon, Moon SY, Lee JY, J Y Lee, Jin Yong Lee
Fertility and Sterility · 2000 · vol. 73(5) , pp. 996–1000 · doi:10.1016/s0015-0282(00)00493-3 · PMID:10785227 · W2157528128
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This study investigated insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP-3 protease activity in the peritoneal fluid of patients with and without endometriosis.

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Abstract

ObjectiveTo compare levels of insulin-like growth factor (IGF) components in the peritoneal fluid of patients with and without endometriosis.DesignPatients with endometriosis were compared with control patients.SettingSeoul National University Hospital, Korea.Patient(s)Forty-three patients with endometriosis and 20 patients without endometriosis.Intervention(s)Peritoneal fluid specimens were collected.Main outcome measure(s)Insulin-like growth factors, IGF binding protein (IGFBP) profiles and IGFBP-3 protease activity.Result(s)The IGF-I levels in peritoneal fluid were significantly higher in patients with endometriosis than in control patients, while the IGFBP-3 levels and the relative proportion of IGFBP-2 in peritoneal fluid were significantly lower in patients with endometriosis than in control patients. However, IGF-II levels, IGFBP-4 profiles, and IGFBP-3 protease activity did not differ significantly between the two groups. No correlation between these IGF components in peritoneal fluid and the stage of endometriosis was noted.Conclusion(s)The profiles of IGF components in peritoneal fluid of patients with pelvic endometriosis may play an important role in the growth of ectopic endometrium and endometriosis-induced infertility.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Endometriosis Endopeptidases Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor I Insulin-Like Growth Factor II Adult Ascitic Fluid Body Mass Index Endometriosis Endopeptidases Humans Insulin-Like Growth Factor Binding Proteins Insulin-Like Growth Factor I Insulin-Like Growth Factor II Molecular Weight

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