O inibidor Btk Ibrutinib limita o desenvolvimento da endometriose em camundongos

Luiza Gama Coelho Riccio
In: Universidade de São Paulo · 2021 · doi:10.11606/t.5.2021.tde-28102021-134952 · W3208619609
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Ibrutinib, a BTK inhibitor, was shown to limit endometriosis development in a mouse model by suppressing the growth and inflammatory response of peritoneal macrophages.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This dissertation studies whether pharmacologic inhibition of Bruton’s tyrosine kinase (Btk) with ibrutinib affects the development of endometriosis-like lesions in mice, using an established murine model with in vivo treatment of operated animals. The work uses measures including ultrasound-based assessment of implant size, histology, and mechanistic readouts such as RT-qPCR, flow cytometry of spleen and peritoneal cells, and cytokine quantification by ELISA. A stated limitation is that, as a thesis, the study is constrained to its specific animal model, endpoints, and experimental design rather than direct human validation. This paper is centrally about endometriosis — it tests whether ibrutinib limits endometriosis development in mice.

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