Expression of Cyclooxygenase-2 in Eutopic Endometrium and Ovarian Endometriotic Tissue in Women with Severe Endometriosis

SiHyun Cho, Soo Hyeon Park, Young Sik Choi, Seok Kyo Seo, Hye Yeon Kim, Ki Hyun Park, Dong Jae Cho, Byung Seok Lee
Gynecologic and obstetric investigation · 2009 · vol. 69(2) , pp. 93–100 · doi:10.1159/000261017 · PMID:20068324 · W2084666971
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Cyclooxygenase-2 expression is increased in the eutopic endometrium and ovarian endometriotic tissue of women with endometriosis, correlating with serum CA-125 and endometrioma size.

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Abstract

BACKGROUND/AIMS: The purpose of this study is to evaluate the level and pattern of cyclooxygenase-2 (Cox-2) expression in endometriosis and to investigate the correlation between the expression of Cox-2 and several clinicosurgical parameters. METHODS: Twenty-six patients with endometriosis and 21 patients with other benign gynecological conditions were enrolled. The eutopic endometrium was sampled by pipelle, and fragments of ovarian endometrioma and non-endometriotic ovarian cysts were sampled during surgery. Total RNA isolation and semiquantitative reverse transcriptase polymerase chain reaction was performed. RESULTS: The expression of Cox-2 mRNA (mean +/- SEM) in eutopic endometrium and ovarian endometriotic tissue significantly increased in patients with endometriosis compared with the controls. The expression of Cox-2 increased significantly in the proliferative phase in eutopic endometrium and in the secretory phase in ovarian endometriotic tissue of patients with endometriosis compared with the controls. Cox-2 mRNA expression in the endometrium and ovarian lesions significantly correlated with serum CA-125 and the diameter of the endometrioma. CONCLUSIONS: Cox-2 expression increased in the eutopic endometrium and ovarian endometriotic tissue of the patients with endometriosis. These findings indicate that Cox-2 may be involved in the pathogenesis and progression of endometriosis.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Cyclooxygenase 2 Endometriosis Ovarian Diseases Adult CA-125 Antigen CA-125 Antigen Cyclooxygenase 2 Cyclooxygenase 2 Endometriosis Endometriosis Endometriosis Female Gene Expression Regulation, Enzymologic Humans Ovarian Diseases Ovarian Diseases Ovarian Diseases Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger RNA, Messenger

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (23)

Cited by (36)

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