Regression of Experimentally Induced Endometriosis with a New Selective Cyclooxygenase-2 Enzyme Inhibitor

İsmail Kılıço, Ismail Kilico, Arif Kökçü, Arif Kokcu, Mehmet Kefeli, Bedrı Kandemır, Bedri Kandemir
Gynecologic and obstetric investigation · 2013 · vol. 77(1) , pp. 35–39 · doi:10.1159/000356686 · PMID:24296832 · W1971047634
article OA: closed CC0 ⤵ 10 in-corpus citations
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Dexketoprofen trometamol, a selective COX-2 inhibitor, significantly reduced the size, weight, and tissue components of experimentally induced endometriotic cysts in rats.

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Abstract

BACKGROUND: Cyclooxygenase-2 (COX-2) levels increase in women with endometriosis. COX-2, via increasing prostaglandin E2, contributes to an increase in vascular endothelial growth factor. In this way, COX-2 may contribute to the progression and continuity of endometriosis. We investigated the effect of dexketoprofen trometamol, a new selective COX-2 enzyme inhibitor, on experimentally induced endometriotic cysts. METHODS: Experimental endometriotic cysts were created in 60 adult female Wistar albino rats. The rats were randomized to 2 equal groups, a control (group Con) and a dexketoprofen (group Dex) group. Six weeks later, cyst volumes were measured as in vivo (volume 1). Following volume 1 measurement, for 4 weeks group Con received 0.1 ml distilled water; group Dex received 0.375 mg dexketoprofen trometamol/0.1 ml distilled water, intramuscularly, twice a day. At the end of administration, the cyst volumes were remeasured (volume 2), and the cysts totally excised and weighed. Glandular (GT) and stromal tissues (ST) and natural killer (NK) cell contents in the cyst wall were scored. RESULTS: NK cell content and volume 1 were not different between the 2 groups. Volume 2, cyst weight, and GT and ST contents in group Dex were significantly lower than those in group Con. CONCLUSION: Dexketoprofen trometamol significantly reduced the development of experimentally induced endometriotic cysts both macroscopically and microscopically.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cyclooxygenase 2 Inhibitors Endometriosis Ketoprofen Tromethamine Animals Cyclooxygenase 2 Inhibitors Disease Models, Animal Endometriosis Endometriosis Endometriosis Female Ketoprofen Ketoprofen Killer Cells, Natural Killer Cells, Natural Random Allocation Rats Rats, Wistar Statistics, Nonparametric Tromethamine

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