Association between Genetic Variants of the VEGFR-2 Gene and the Risk of Developing Endometriosis in Northern Chinese Women

Shan Kang, Yuanyuan Shi, Yuan-yuan Shi, Yan Li, Na Wang, Yuchao Lu, Yu-chao Lu, Rong‐Miao Zhou, Rong-miao Zhou, Xi-wa Zhao, Xiwa Zhao
Gynecologic and obstetric investigation · 2013 · vol. 76(1) , pp. 32–37 · doi:10.1159/000350665 · PMID:23635398 · W2019620365
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This study genotyped five tag single nucleotide polymorphisms in the VEGFR-2 gene in Northern Chinese women and found that the 1192C/T polymorphism was associated with a reduced risk of endometriosis.

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Abstract

AIM: To investigate the association of tag single nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor receptor 2 (VEGFR-2) gene with susceptibility to endometriosis. METHODS: This study comprised 571 patients with endometriosis and 580 women in the control group. Five tag SNPs in the VEGFR-2 gene were selected using a Haploview program, and those SNPs were genotyped by a method of polymerase chain reaction and ligase detection reaction. RESULTS: Statistical results show that there was a significant difference in the genotype and allele distribution of the 1192C/T polymorphism between the disease group and the control group (p = 0.041 and 0.017). The women carrying the T allele (C/T+T/T genotype) had a lower risk of developing endometriosis compared with the women with the C/C genotype (OR 0.75, 95% CI 0.57-0.99). There was no significant difference in the allele and genotype distribution of four other tag SNPs (1719T/A, +31C/T, IVS25-92A/G and IVS6+​54C/T) between the disease group and the control group (all p > 0.05). CONCLUSIONS: Our results suggested that the 1192C/T polymorphisms on the VEGFR-2 gene might affect the risk of developing endometriosis in Northern Chinese women of Han ethnicity.

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Condition tags

endometriosis

MeSH descriptors

Asian People Endometriosis Vascular Endothelial Growth Factor Receptor-2 Asian People Case-Control Studies China Chi-Square Distribution DNA DNA DNA Endometriosis Endometriosis Female Genetic Predisposition to Disease Genetic Variation Haplotypes Humans Polymerase Chain Reaction Polymorphism, Single Nucleotide Vascular Endothelial Growth Factor Receptor-2

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