Human Chorionic Gonadotropin Improves Endometriosis Through Downregulation of Leptin Expression in Rats

Ling-Ling Wu, Lingling Wu, Rui-Ping Pang, Rui‐Ping Pang, Yuzhu Yin, Yu-Zhu Yin, Kai-Feng Shen, Kai‐Feng Shen, Peizhen Zhang, Pei-Zhen Zhang
Gynecologic and obstetric investigation · 2015 · vol. 79(3) , pp. 189–194 · doi:10.1159/000367655 · PMID:25722014 · W2025500310
article OA: closed CC0 ⤵ 3 in-corpus citations
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Human chorionic gonadotropin treatment reduced endometriotic lesion volume in rats by downregulating leptin expression in endometrial tissues.

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Abstract

OBJECTIVE: To investigate whether and how human chorionic gonadotropin (HCG) treatment ameliorates endometriosis in an endometriotic rat model. METHODS: Twenty-four endometriosis rats were established and were randomly divided into four groups, and then the rats were treated with 19.4, 25.8, and 51.6 IU/100 g weight/day of HCG, respectively. The control group was treated with 0.9% NaCl. After 15 days (3 estrous cycles), the ectopic lesion volume and the expression of leptin protein in eutopic and ectopic endometrium were investigated. RESULTS: After HCG treatment, the volumes of endometriotic lesions were significantly smaller than those before treatment. During endometriosis development, the expression of leptin protein in eutopic and ectopic endometrium was remarkably increased. HCG administration reversed leptin upregulation in endometriotic tissues. CONCLUSION: HCG therapy appears to be an effective treatment for endometriosis in rats through down-regulation of leptin expression in eutopic and ectopic endometrium.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Chorionic Gonadotropin Endometriosis Endometrium Leptin Animals Blotting, Western Chorionic Gonadotropin Disease Models, Animal Down-Regulation Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Fluorescent Antibody Technique Humans Leptin Rats Rats, Sprague-Dawley

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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