Evaluation of selected angiogenic and inflammatory markers in endometriosis before and after danazol treatment
article
OA: closed
CC0
⤵ 29 in-corpus citations
AI-generated summary
This study evaluated angiogenic and inflammatory markers in endometriosis patients before and after danazol treatment, finding decreased plasma CA-125 and increased VEGF post-treatment, with no marker combinations achieving >60% diagnostic sensitivity.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Angiogenesis and inflammation are pivotal processes in developing endometriosis in the peritoneal cavity. The aim of the present study was to evaluate these two processes in women with endometriosis who had been treated with danazol to determine the sensitivity of a non-invasive test in diagnosing endometriosis. The clinical follow-up study was conducted in a group of 103 women diagnosed laparoscopically with endometriosis. Thirty-five patients qualified for danazol treatment. Pain was assessed using a visual analogue scale, whereas endometriosis was assessed using the revised American Society of Reproductive Medicine (rASRM) scale. Cancer antigen (CA)-125 and C-reactive protein (CRP) concentrations in plasma and peritoneal fluid were determined by immunoenzymatic methods, whereas vascular endothelial growth factor (VEGF) and interleukin (IL)-1β concentrations in plasma and peritoneal fluid were determined by ELISA. Endometrial expression of IL-8 and platelet-derived growth factor alpha polypeptide (PDGF-A) was determined using real-time polymerase chain reaction (PCR). Women with endometriosis (68.9% of patients) had higher plasma concentrations of CA-125, as well as higher concentrations of both CA-125 and VEGF in the peritoneal fluid. Endometrial expression of IL-8 mRNA was significantly higher, whereas that of PDGF-A was significantly lower, in contrast. After danazol treatment the patients reported lower pain scores; in addition, CA-125 concentrations in the plasma were decreased (P60%. Danazol treatment is highly effective in relieving pain and decreasing CA-125 concentrations in the plasma. Higher plasma concentrations of VEGF after treatment could imply stimulation of angiogenesis.
My notes (saved in your browser only)
Outcome instruments
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (37)
- Association of leptin with inflammatory cytokines and lymphocyte subpopulations in peritoneal fluid of patients with endometriosis via openalex
- Behaviour of Cytokine Levels in Serum and Peritoneal Fluid of Women with Endometriosis via openalex
- Comparison of the effects of leuprorelin acetate and danazol treatments on serum CA-125 levels in women with endometriosis. via openalex
- Effect of dienogest administration on angiogenesis and hemodynamics in a rat endometrial autograft model via openalex
- Effect of GnRH analogues on apoptosis and release of interleukin-1 and vascular endothelial growth factor in endometrial cell cultures from patients with endometriosis via openalex
- Elevated ghrelin levels in the peritoneal fluid of patients with endometriosis: associations with vascular endothelial growth factor (VEGF) and inflammatory cytokines via openalex
- Endometriosis: Diagnosis and Management via openalex
- Expression and regulation of vascular endothelial growth factor ligands and receptors during menstruation and post-menstrual repair of human endometrium via openalex
- Expression of epidermal growth factor, fibroblast growth factor‐2, and platelet‐derived growth factor‐A in the eutopic endometrium of women with endometriosis via openalex
- Interleukin-6 and other soluble factors in peritoneal fluid and endometriomas and their relation to pain and aromatase expression via openalex
- Is Endometriosis Associated with Systemic Subclinical Inflammation? via openalex
- Levels of vascular endothelial growth factor (VEGF) in serum of patients with endometriosis via openalex
- Local Cytokines in Endometrial Tissue: The Role of Interleukin‐8 in the Pathogenesis of Endometriosis via openalex
- Maintenance therapy involving a tapering dose of danazol or mid/low doses of oral contraceptive after gonadotropin-releasing hormone agonist treatment for endometriosis-associated pelvic pain via openalex
- Methodological concerns regarding levels of vascular endothelial growth factor (VEGF) in serum of patients with endometriosis via openalex
- Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers via openalex
- Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities via openalex
- Peritoneal fluid-mediated enhancement of eutopic and ectopic endometrial cell proliferation is dependent on tumor necrosis factor-α in women with endometriosis via openalex
- Revised American Society for Reproductive Medicine classification of endometriosis: 1996 via openalex
- Serum and cyst fluid levels of interleukin (IL) -6, IL-8 and tumour necrosis factor-alpha in women with endometriomas and benign and malignant cystic ovarian tumours via openalex
- Serum levels of VEGF and TNF-α and their association with C-reactive protein in patients with endometriosis via openalex
- [Serum VEGF (vascular endothelial growth factor) concentration in patients with endometriosis]. via openalex
- The Role of GnRH Analogues in Endometriosis-Associated Apoptosis and Angiogenesis via openalex
- Tissue and endocrine responses to gestrinone and danazol in the treatment of endometriosis via openalex
- Vaginal danazol for women with rectovaginal endometriosis and pain symptoms persisting after insertion of a levonorgestrel‐releasing intrauterine device via openalex
- [VEGF concentration in peritoneal fluid of patients with endometriosis]. via openalex
- [VEGF production and its receptor expression of MPhis in peritoneal fluid]. via openalex
- What’s the delay? A qualitative study of women’s experiences of reaching a diagnosis of endometriosis via openalex
- W2057684012 via openalex
- W2049037562 via openalex
- W2140246703 via openalex
- W2025476693 via openalex
- W2155024696 via openalex
- W2004594777 via openalex
- W1985959551 via openalex
- W2102732690 via openalex
- W1972238505 via openalex
Cited by (29)
- An integrated multi-tissue approach for endometriosis candidate biomarkers: a systematic review 2024
- Targeting NGF but not VEGF or BDNF signaling reduces endometriosis-associated pain in mice 2023
- Evaluation of new biomarkers in stage III and IV endometriosis 2023
- How to Improve Non-Invasive Diagnosis of Endometriosis with Advanced Statistical Methods 2023
- Endometriosis Research: From Bench to Bedside 2022
- Endometriosis biomarkers of the disease: an update 2022
- Danazol 2022
- Advances in Treatment of Endometriosis 2022
- Association of VEGF cytokine levels and single nucleotide polymorphisms of the <i>VEGF-A</i> gene with the genital endometriosis in the female population of the Northwestern Federal District of Russia 2022
- Identification of endometriosis-associated genes and pathways based on bioinformatic analysis 2021
- Brief Review of Endometriosis and the Role of Trace Elements 2021
- Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives 2020
- Discerning Endometriosis as a Multifaceted Entity: A Comprehensive Review 2020
- Expression of nerve growth factor (NGF) in endometrium as a potential biomarker for endometriosis – Single tertiary care centre study 2020
- The effects of certain angioneogenesis inhibitors in experimental endometriosis in rats 2019
- Endometriosis — insights into a multifaceted entity 2018
- Biomarkers of endometriosis - current trends 2018
- Biomarkers for Diagnosis of Pre-Eclampsia and Endometriosis 2018
- Impact of a Chinese Medicinal Formula, Xiao Liu Fang, on the “3A” Ability of Endometrial Stromal Cells in Patients with Endometriosis 2018
- Abnormal peritoneal regulation of chemokine activation—The role of <scp>IL</scp>‐8 in pathogenesis of endometriosis 2017
- Peripheral Blood Biomarkers for Endometriosis 2017
- Endometriosis-associated changes in serum levels of interferons and chemokines 2017
- Blood biomarkers for the non-invasive diagnosis of endometriosis 2016
- Is it possible to diagnose endometriosis at the level of endometrium? 2016
- Combination of the non-invasive tests for the diagnosis of endometriosis 2016
- Clear cell ovarian cancer and endometriosis: is there a relationship? 2016
- Endometriosis: where are we and where are we going? 2016
- Update on Biomarkers for the Detection of Endometriosis 2015
- Human Chorionic Gonadotropin Improves Endometriosis Through Downregulation of Leptin Expression in Rats 2015
Source provenance
- europepmc
- last seen: 2026-06-11T06:19:48.454388+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:19:05.543671+00:00
License: CC0
· commercial use OK