Association of VEGF cytokine levels and single nucleotide polymorphisms of the VEGF-A gene with the genital endometriosis in the female population of the Northwestern Federal District of Russia

Natalia V Kulikova, Л. С. Литвинова, Н. В. Шперлинг, А. В. Иванов
In: Gynecology · 2022 · vol. 24(4) , pp. 289–293 · doi:10.26442/20795696.2022.4.201771 · W4298142251
article OA: gold CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study found associations between specific VEGF-A gene polymorphisms and genital endometriosis risk, with lower VEGF-A cytokine levels observed in endometriosis patients compared to controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study examined associations between VEGF-A neoangiogenesis gene polymorphisms C(-460)T (rs833061) and C(+936)T (rs3025039) and the risk of genital endometriosis, and whether these variants relate to circulating VEGF-A levels. The authors genotyped 85 women with histologically confirmed genital endometriosis and 79 laparoscopically evaluated controls, and measured serum VEGF-A by ELISA, analyzing genotype/allele frequencies with χ2/Fisher tests. They found that the C allele and CC genotype of rs3025039 were associated with increased odds of genital endometriosis (OR ~2.35 and ~1.89), while TT-related variants were less common in cases; additionally, serum VEGF-A was reported as markedly lower in endometriosis and differed by rs3025039 genotype, with explicit statements that VEGF-A was decreased 2.5-fold in patients. The paper does not provide key limitations beyond requiring further analysis for prognosis/therapy efficacy, and it includes only women from a specific Russian region with relatively modest sample size. This paper is centrally about endometriosis — it analyzes VEGF-A gene polymorphisms and serum VEGF-A differences in women with genital endometriosis.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Aim. To study the association of neoangiogenesis VEGF-A gene polymorphisms C(-460)T (rs833061), C(+936)T (rs3025039) with the risk of genital endometriosis in the population of the Northwestern Federal District; to examine the relationship of polymorphic variants of the VEGF-A neoangiogenesis gene C(-460)T (rs833061), C(+936)T (rs3025039) with the concentration of VEGF-A factor in the blood of females with genital endometriosis. Materials and methods. Eighty-five female volunteers aged from 19 to 44 (mean age 32.9 (5.8) years) with a histologically confirmed diagnosis of genital endometriosis were included in the stud; also, 79 females without endometriosis according to diagnostic laparoscopy for infertility or ectopic pregnancy, aged 20 to 42 (mean age 32.5 (7.2) years, p=0.71) were included in the study. The obtained data were analyzed using SPSS 20.0 statistical software package; 2 value and p value were estimated. Results. In our study, we found an association between the C allele and the CC genotype of the C(+936)T (rs3025039) polymorphism of the VEGF-A gene with genital endometriosis: odds ratio (OR) 2.35, 95% confidence interval (CI) 1.034.61, p=0.023; OR 1.89, 95% CI 1.034.61, p=0.048, respectively. The TT genotype of the C(-460)T (rs833061) polymorphisms and the TT genotype and the C(+936)T (rs3025039) allele of the VEGF-A gene were less common in patients with genital endometriosis: OR 0.43, 95% CI 0.141.29, p=0.023; OR 0.06, 95% CI 0.043.18, p=0.001; OR 0.43, 95% CI 0.231.29, p=0.023 respectively. The blood concentration of VEGF-A cytokine was lower in patients with genital endometriosis at all genotypes of C(-460)T (rs833061) locus of VEGF-A gene than that in females without endometriosis. The analysis of genotype frequency distribution of polymorphic site C(+936)T of the VEGF-A gene showed that the VEGF-A cytokine level was 1.5 times higher in the comparison group with heterozygous ST genotype versus that in homozygous genotypes. Enzyme immunoassay in the examined females showed a 2.5-fold decrease in the level of the VEGF-A angiogenic cytokine in blood serum in patients with endometriosis compared to those without endometriosis. Conclusion. To better understand the pathogenetic features of the endometriosis course and to make an individual prognosis of the course and therapy efficacy, an additional analysis of the associations between the polymorphisms of the listed genes and the angiogenesis factor level is required.

My notes (saved in your browser only)

Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK