Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis

Purpose The vascular endothelial growth factor (VEGF) gene polymorphism has been reported to be associated with endometriosis risk. The purpose of the present study was to perform a comprehensive meta-analysis to explore whether VEGF gene polymorphisms confer risk to endometriosis.

By searching PubMed and EMBASE databases, a total of 11 studies were identified. Crude odds ratio (OR) and their corresponding 95% confidence intervals (CI) for VEGF gene polymorphisms and endometriosis risk were calculated.

An association of VEGF gene +936TC polymorphism with endometriosis was found (Fixed-effect model: TT + TC vs. CC: OR 1.184, 95% CI 1.027–1.366, P = 0.020; TC vs. CC: OR 1.187, 95% CI 1.024–1.375, P = 0.023. Random-effcet model: TT + TC vs. CC: OR 1.203, 95% CI 1.003–1.443, P = 0.046; TC vs. CC: OR 1.188, 95% CI 1.021–1.382, P = 0.026). No association between VEGF genes −460CT, +405CG, −2578AC, −1154GA polymorphisms and endometriosis was observed.

Our results indicate that VEGF +936TC gene polymorphism is a risk factor for endometriosis, and not −460CT, +405CG, −2578AC, −1154GA. Similar content being viewed by others

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Conflict of interest The authors declare that they have no conflicts of interest relevant to the manuscript. Author information Authors and Affiliations Corresponding author Rights and permissions About this article Cite this article Liang, S., Huang, Y. & Fan, Y. Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis. Arch Gynecol Obstet 286, 139–146 (2012). https://doi.org/10.1007/s00404-012-2270-1 Received: Accepted: Published: Issue date: DOI: https://doi.org/10.1007/s00404-012-2270-1