Genetic polymorphisms of Vascular Endothelial Growth Factor (VEGF) associated with endometriosis in Nigerian women

Ochuwa Adiketu Babah, Oyesola Ojewunmi, Oyesola Oyewole Ojewunmi, Akinniyi Osuntoki, Akinniyi Adediran Osuntoki, Melissa A Simon, Bosede Bukola Afolabi
Human genomics · 2021 · vol. 15(1) , pp. 64 · doi:10.1186/s40246-021-00364-x · PMID:34717756 · PMC8556990 · W3210236175
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Abstract

OBJECTIVE: To determine if genetic polymorphism of VEGF is associated with the development of endometriosis in Nigerian women. STUDY DESIGN: Case control study of 100 women (50 healthy controls and 50 with endometriosis). Serum VEGF concentration of participants were determined using enzyme-linked immunosorbent assay (ELISA) technique. Genomic DNAs were isolated from peripheral blood samples and quantified by nanodrop spectrophotometer one. Single nucleotide polymorphisms genotyping was carried out by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). RESULTS: Mean age of participants was 32.96 ± 6.91 years for control and 32.04 ± 7.56 years for cases. VEGF levels in case and control groups were not statistically different (82.68 pg/ml [69.11-121.11 pg/ml] vs. 82.81 pg/ml [72.90-113.82 pg/ml] respectively; p = 0.967). All four genotypes examined were in Hardy-Weinberg equilibrium. Minor allele frequency of - 460T > C, - 1154G > A, + 936C > T and + 2578C > A were 24%, 8%, 6% and 10% in the control and 19%, 9%, 5% and 14% in endometriosis patients. However, allele and genotype distributions of - 460T > C, - 1154G > A, + 936C > T and + 2578C > A VEGF polymorphisms in endometriosis patients and control were not significantly different (p > 0.05). CONCLUSION: Our preliminary findings revealed no association between endometriosis and - 460T > C, - 1154G > A, + 936C > T and + 2578C > A of VEGF genes among Nigerian women.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Vascular Endothelial Growth Factor A Adult Case-Control Studies Female Genetic Predisposition to Disease Genotype Humans Nigeria Polymorphism, Single Nucleotide Polymorphism, Single Nucleotide Vascular Endothelial Growth Factor A

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chemicals 7
nucleotide glycoprotein water agarose ethidium bromide bromophenol blue
organisms 2
noordeloos 2009062 noordeloos 2009062

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