Vascular endothelial growth factor +936 C/T polymorphism is associated with an increased risk of endometriosis in a Japanese population

Yoshiyuki Ikuhashi, Ikuhashi Y, Shigeki Yoshida, Yoshida S, Kennedy S, Stephen Kennedy, Krina Zondervan, Krina T. Zondervan, Naoya Takemura, Takemura N, Deguchi M, Masashi Deguchi, Ohara N, Noriyuki Ohara, Takeshi Maruo, Maruo T
Acta obstetricia et gynecologica Scandinavica · 2007 · vol. 86(11) , pp. 1352–1358 · doi:10.1080/00016340701644991 · PMID:17963063 · W2107988224
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The VEGF +936 T allele was associated with an increased risk of stage III-IV endometriosis in a Japanese population.

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Abstract

BACKGROUND: Vascular endothelial growth factor (VEGF) concentration in endometriosis patients is higher than controls, in serum and ascites, suggesting that VEGF may play an important role in the pathogenesis of endometriosis. In this study, we investigated whether polymorphisms in the VEGF gene are associated with endometriosis in a Japanese population. METHODS: Genotyping of VEGF -460 C/T, +405 G/C and +936 C/T polymorphisms were performed in 147 endometriosis cases diagnosed by laparotomy or laparoscopy at a university hospital, and 181 controls, by polymerase chain reaction-restriction fragment length polymorphism analysis. We compared the genotype distribution and allele frequency of these 3 polymorphisms between endometriosis patients and controls. RESULTS: No significant differences in the frequency and genotype distribution of VEGF -460 C/T, +405 G/C and +936 C/T polymorphisms were found between the endometriosis patients (all disease stages) and controls. However, a positive association was found between stage III-IV disease and the VEGF +936 T allele (p=0.018). CONCLUSIONS: The VEGF +936 T allele is associated with an increased risk of stage III-IV endometriosis in a Japanese population.

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Condition tags

endometriosis

MeSH descriptors

Asian People Endometriosis Endometriosis Polymorphism, Genetic Vascular Endothelial Growth Factor A Adult Asian People Case-Control Studies Endometriosis Endometriosis Female Genetic Predisposition to Disease Genetic Predisposition to Disease Humans Infant, Newborn Linkage Disequilibrium Linkage Disequilibrium Polymorphism, Genetic Severity of Illness Index Vascular Endothelial Growth Factor A

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