Vascular endothelial growth factor (−460 C/T, +405 G/C, and +936 C/T) polymorphisms and endometriosis risk in Tunisian population

Belkis Henidi, Wajih Kaabachi, Abir Naouali, Safa Kaabachi, A. Zhioua, Amel Zhioua, Faycal Haj Sassi, Fayçal Haj Sassi, Kamel Hamzaoui
Systems biology in reproductive medicine · 2015 · vol. 61(4) , pp. 238–244 · doi:10.3109/19396368.2015.1041622 · PMID:25984730 · W1879063215
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Abstract

The vascular endothelial growth factor (VEGF), a major angiogenic factor, is known to play an important role in the development of endometriosis. The aim of this study was to investigate the association of three VEGF (-460 C/T, +405 G/C, and +936 C/T) polymorphisms with the risk of endometriosis in the Tunisian population. This study includes 105 women with endometriosis and 150 women with no laparoscopic evidence of disease. Genotyping of the VEGF -460 C/T, +405 G/C, and +936 C/T polymorphisms were performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The distribution of genotypes (P = 0.006) and allele (P = 0.0009) frequencies of the +936 C/T polymorphism was significantly different between patients and controls. Patients with stages III-IV endometriosis showed a higher VEGF + 936T allele frequency than controls (P = 0.0001). However, the distribution of genotypes and allele frequencies of the VEGF -460 C/T and +405 G/C polymorphisms did not differ significantly between endometriosis patients and controls. These findings suggest that the VEGF +936 C/T polymorphism may be a risk factor for endometriosis development and the VEGF +936 T allele is associated with an increased risk of stages III-IV endometriosis in the Tunisian population.

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mesh:D004715endometriosis

MeSH descriptors

Endometriosis Genetic Predisposition to Disease Polymorphism, Genetic Vascular Endothelial Growth Factor A Case-Control Studies Endometriosis Female Gene Frequency Haplotypes Humans Tunisia Vascular Endothelial Growth Factor A

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