Serum and peritoneal fluid levels of vascular endothelial growth factor in women with endometriosis.

Maryam Kianpour, Mehdi Nematbakhsh, Sayad Mehdi Ahmadi, Mehrangiz Jafarzadeh, Masomeh Hajjarian, Zahra Pezeshki, Tahereh Safari, Fatemeh Eshraghi-Jazi
International journal of fertility & sterility · 2013 · vol. 7(2) , pp. 96–9 · PMID:24520470 · PMC3850339 · W2319439373
article OA: gold CC0 ⤵ 37 in-corpus citations
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Abstract

BACKGROUND: Endometriosis is known as one of the most common disease in women of reproductive age. Due to important role of vascular endothelial growth factor (VEGF) in neo-vascularization for the implantation of endometrial cell, and also presence of different studies reported VEGF level in the serum and peritoneal fluid (PF) in endometriosis patients, this study was designed to determine the serum and PF levels of VEGF in endometriosis patients, and to compare with normal subjects. MATERIALS AND METHODS: In this descriptive study, 179 women subjected to laparoscopy for the evaluation of infertility or pelvic pain were allocated into the following two groups: group I: different types of endometriosis patients (n=90) and group II: non-endometriosis patients (n=89). The PF from pelvis and venous blood samples were obtained. The VEGF concentration of the serum and PF were measured using enzyme immunoassay kit and were compared using t test. RESULTS: The level of VEGF in serum was significantly less than that in PF in both groups (p=0.00). However, endometriosis patients had significantly higher level of VEGF in peritoneal fluid than non-endometriosis patients (p=0.043). CONCLUSION: According to our findings, endometriosis is not associated with change in the level of circulating VEGF.

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endometriosisinfertility

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