The Correlation between Serum and Peritoneal Fluid CA125 Level in Women with Pelvic Endometriosis

Royan Institue, Shadab Salehpour, Azadeh Akbari Sene, Ebrahim Kalantarian Mehrjerdi, Ph. D, Mohammad Reza Akhoond, M. Sc
In: http://sid.ir/en/VEWSSID/J_pdf/107320090106.pdf · 2009 · doi:10.22074/ijfs.2009.45743 · W3141051327
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found significantly higher serum and peritoneal fluid CA125 levels in women with endometriosis compared to controls, with levels correlating with disease stage.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This cross-sectional study enrolled 60 women undergoing laparoscopy for benign conditions and compared 35 with pelvic endometriosis versus 25 without, measuring serum and peritoneal fluid CA125 using an electrochemiluminescence immunoassay. Mean CA125 levels were significantly higher in women with endometriosis than controls in both serum (26.42 ± 24.34 IU/ml vs 12.64 ± 6.87 IU/ml) and peritoneal fluid (2203.54 ± 993.19 IU/ml vs 1583.42 ± 912.51 IU/ml), and CA125 varied with stage, with significant differences mainly in higher stages. The study proposed diagnostic cut-offs of 14.70 IU/ml (serum) and 1286.5 IU/ml (peritoneal fluid) and found a linear correlation between serum and peritoneal fluid CA125 in endometriosis patients. The paper’s main caveat is that all participants were selected from women already undergoing laparoscopy, which may limit generalizability beyond this diagnostic context. This paper is centrally about endometriosis — it evaluates serum and peritoneal fluid CA125 levels as diagnostic and staging biomarkers for pelvic endometriosis.

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Abstract

Background: Despite a high prevalence of endometriosis, there still exist many challenges in diagnosing the disease. This study aims to evaluate non-invasive and practical diagnostic methods by measuring serum and peritoneal fluid CA 125 levels in patients with endometriosis. A secondary aim is to determine the correlation between these markers with the stage of disease as well as the relationship of the two markers with each other. Materials and Methods: This is a cross-sectional study of 60 women who underwent laparoscopy for benign conditions. Based on laparoscopic findings and biopsy results, patients were divided to two groups; one group included patients with pelvic endometriosis (35 patients) and the second enrolled patients free from endometriosis (25 patients). Serum and peritoneal fluid specimens were provided at the time of laparoscopy and CA125 levels were then assessed by electrochemiluminescence immunoassay. Results: Mean serum and peritoneal fluid CA125 levels were significantly higher in women with endometriosis as compared to the control group (26.42 ± 24.34 IU/ml versus 12.64 ± 6.87 IU/ml in serum and 2203.54 + 993.19 IU/ml versus 1583.42 ± 912.51 IU/ml in peritoneal fluid, p<0.05). CA 125 levels also varied proportionally with the stage of endometriosis; but showed a significant
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International Journal of Fertility and Sterility (May 2009) The Correlation between Serum and Peritoneal Fluid CA125 Level in Women with Pelvic Endometriosis Abstract Background Despite a high prevalence of endometriosis, there still exist many challenges in diagnosing the disease. This study aims to evaluate non-invasive and practical diagnostic methods by measuring serum and peritoneal fluid CA 125 levels in patients with endometriosis. A secondary aim is to determine the correlation between these markers with the stage of disease as well as the relationship of the two markers with each other. Materials and methods This is a cross-sectional study of 60 women who underwent laparoscopy for benign conditions. Based on laparoscopic findings and biopsy results, patients were divided to two groups; one group included patients with pelvic endometriosis (35 patients) and the second enrolled patients free from endometriosis (25 patients). Serum and peritoneal fluid specimens were provided at the time of laparoscopy and CA125 levels were then assessed by electrochemiluminescence immunoassay. Results Mean serum and peritoneal fluid CA125 levels were significantly higher in women with endometriosis as compared to the control group (26.42 ± 24.34 IU/ml versus 12.64 ± 6.87 IU/ml in serum and 2203.54 + 993.19 IU/ml versus 1583.42 ± 912.51 IU/ml in peritoneal fluid, p<0.05). CA 125 levels also varied proportionally with the stage of endometriosis; but showed a significant difference only in higher stages of the disease, both in serum and peritoneal fluid. We calculated the cut-off value suggesting a diagnosis of pelvic endometriosis as 14.70 IU/ml for serum and 1286.5 IU/ml for peritoneal fluid CA125. A linear correlation between CA 125 levels in serum and peritoneal fluid in patients with pelvic endometriosis has also been observed. Conclusion Serum and peritoneal fluid CA 125 levels are simple and non-surgical tools for diagnosing and staging pelvic endometriosis. These markers are of greater diagnostic value in higher stages of the disease. Keywords

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