The Effect of Surgical Intervention of Endometriosis to CA-125 and Pain
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⤵ 6 in-corpus citations
Abstract
Endometriosis is an inflammatory condition characterised by the presence of endometrial growth beyond the uterine cavity. It is a debilitating disease requiring multiple modalities of treatment. In considering surgery as the option of treatment, the benefits should outweigh the risk. Besides direct surgical risk, intervention may lead to a reduction of ovarian reserve, in addition to premature menopause and low fecundity. To date, there is an inconclusive evidence to support any specific parameters in monitoring disease progression following surgical intervention. Serum cancer antigen (CA)-125 is expressed by coelomic epithelium and has been extensively studied as a biomarker for endometriosis. Elevated expression of CA-125 has been shown in endometrial tissues and the marker increased indirectly from peritoneal irritation that accompanies an extensive form of endometriosis. Additionally, the visual analogue scale (VAS) scores have been used as an objective measurement for measuring pain, especially in a complex disease such as endometriosis. This review aims to consolidate a series of clinical trials that utilised CA-125 level and VAS score as tools for monitoring patients undergoing surgery for endometriosis.
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Cited by (6)
- CA125 Outperforms HE4 and CA19-9 as a Serum Biomarker for Preoperative Diagnosis of Ovarian Endometriomas: A Retrospective Cohort Study 2026
- Revisão de literatura sobre a menopausa em mulheres com diagnóstico de endometriose pélvica 2025
- PTEN and PI3K Mutation Markers and Expression of CD68 and IL-6 Inflammatory Markers in Endometrioid and Clear Cell Ovarian Carcinoma with Underlying Endometriosis 2024
- Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review 2023
- Comparison of Pain Severity with VAS Score in Preoperative and Postoperative Periods After Laparoscopic Cystectomy in Isolated Endometriomas 2022
- Clinical efficacy of turtle shell decocted pills for endometriosis and their influence on cellular immunity. 2022
Source provenance
- europepmc
- last seen: 2026-06-20T06:14:18.781669+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:24:55.077982+00:00
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