What is the source of elevated serum levels of CA 125 in patients with endometriosis?

Luigi Fedele, L Fedele, Luisa Arcaini, Arcaini L, L Arcaini, A Baglioni, Baglioni A, S Bianchi, Stefano Bianchi, Menard S, Silvie Menard, S Menard
European journal of obstetrics, gynecology, and reproductive biology · 1989 · vol. 33(3) , pp. 247–252 · doi:10.1016/0028-2243(89)90137-8 · PMID:2689251 · W1969621444
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This paper investigates the origins of elevated serum CA 125 levels observed in patients diagnosed with endometriosis.

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Abstract

The presence of CA 125 was investigated in endometriotic tissue and endometrial mucosa using two different immunohistochemical methods, indirect immunofluorescence and the avidin-biotin immunoperoxidase technique. Neither of the methods revealed the antigen in the 12 endometriotic fragments studied. The endometrial mucosa both of patients with endometriosis and of the control subjects was positive with indirect immunoperoxidase staining in all cases, whereas with indirect immunofluorescence it was positive in 75 and 67%, respectively. Thus the mechanism(s) responsible for distribution of the antigen in different tissues and its reported high serum levels in advanced endometriosis is still unclear.

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Condition tags

endometriosis

MeSH descriptors

Antigens, Tumor-Associated, Carbohydrate Endometriosis Uterine Neoplasms Adult Antigens, Tumor-Associated, Carbohydrate Endometriosis Endometriosis Female Fluorescent Antibody Technique Humans Immunoenzyme Techniques Neoplasm Staging Uterine Neoplasms Uterine Neoplasms Uterine Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (9)

Cited by (6)

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europepmc
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License: CC0 · commercial use OK