Reviewing the role of progesterone therapy in endometriosis
review
OA: closed
CC0
⤵ 25 in-corpus citations
AI-generated summary
This review consolidates clinical trials examining progestins and their mechanisms for treating endometriosis, highlighting progesterone resistance as a key factor and discussing progesterone receptor modulators as potential therapeutic targets.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
Endometriosis is a benign, chronic inflammatory condition characterized by the presence and growth of endometrial implants outside the uterine cavity. The cause of endometriosis is multifactorial. It is due to the diversity of hypothesis and plausibility of hormonal alterations which could play a major role. Evidence has shown that progesterone resistance is a key factor for endometriosis sufferers. Medical therapy can avoid surgical intervention, which may lead to a reduced in ovarian reserve, and its effects of earlier menopause and reduced fecundity. Progesterone receptor isoform has provided new insight as the potential treatment. Progestin, anti-progestin and selective progesterone receptor modulators usage, which target these receptors, could avoid hypo-estrogenic side effects, which can be debilitating. Numerous types of these medications have been used on and off labeled to treat endometriosis with varying success. This review aims to consolidate series of clinical trials using progestins in endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (66)
- A case report of thoracic endometriosis – A rare cause of haemothorax via openalex
- A dose‐ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis via openalex
- Changes in quality of life after hormonal treatment of endometriosis via openalex
- Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis via openalex
- Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol<sup>1</sup> via openalex
- Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis via openalex
- Detailed analysis of a randomized, multicenter, comparative trial of dienogest versus leuprolide acetate in endometriosis via openalex
- Dienogest and deep infiltrating endometriosis: The remission of symptoms is not related to endometriosis nodule remission via openalex
- Dienogest for Treatment of Endometriosis in Chinese Women: A Placebo-Controlled, Randomized, Double-Blind Phase 3 Study via openalex
- Dienogest increases the progesterone receptor isoform B/A ratio in patients with ovarian endometriosis via openalex
- Dienogest in the treatment of endometriosis-associated pelvic pain: a 12-week, randomized, double-blind, placebo-controlled study via openalex
- Dienogest is as effective as intranasal buserelin acetate for the relief of pain symptoms associated with endometriosis—a randomized, double-blind, multicenter, controlled trial via openalex
- Effective post-laparoscopic treatment of endometriosis with dydrogesterone via openalex
- Effect of dienogest on pain and ovarian endometrioma occurrence after laparoscopic resection of uterosacral ligaments with deep infiltrating endometriosis via openalex
- Effects of long-term postoperative dienogest use for treatment of endometriosis on bone mineral density via openalex
- Efficacy and acceptability of long-term norethindrone acetate for the treatment of rectovaginal endometriosis via openalex
- Efficacy of dienogest in improving pain in women with endometriosis: a 12-month single-center experience via openalex
- Efficacy of medroxyprogesterone treatment in infertile women with endometriosis: a prospective, randomized, placebo-controlled study via openalex
- Efficacy of Norethisterone in Patients with Ovarian Endometrioma via openalex
- Efficacy of the levonorgestrel-releasing intrauterine device in the treatment of recurrent pelvic pain in multitreated endometriosis. via openalex
- Elagolix, an Oral GnRH Antagonist, Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis: Effects on Bone Mineral Density via openalex
- Endometriosis via openalex
- Endometriosis via openalex
- Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex
- Endometriosis: the pathophysiology as an estrogen-dependent disease via openalex
- Eutopic Endometrium From Women With Endometriosis Shows Altered Ultrastructure and Glycosylation Compared to That From Healthy Controls—A Pilot Observational Study via openalex
- Expression of the gamma 2 chain of laminin-332 in eutopic and ectopic endometrium of patients with endometriosis via openalex
- Gonadotropin-releasing hormone agonist with add–back treatment is as effective and tolerable as dienogest in preventing pain recurrence after laparoscopic surgery for endometriosis via openalex
- Low-dose add-back therapy during postoperative GnRH agonist treatment via openalex
- Oral continuous combined 0.5 mg estradiol valerate and 5 mg dydrogesterone as daily add-back therapy during post-operative GnRH agonist treatment for endometriosis in Chinese women. via openalex
- Postoperative administration of dienogest plus estradiol valerate versus levonorgestrel‐releasing intrauterine device for prevention of pain relapse and disease recurrence in endometriosis patients via openalex
- Postoperative Levonorgestrel-Releasing Intrauterine System for Pelvic Endometriosis-Related Pain via openalex
- Postoperative Levonorgestrel-Releasing Intrauterine System Insertion After Gonadotropin-Releasing Hormone Agonist Treatment for Preventing Endometriotic Cyst Recurrence: A Prospective Observational Study via openalex
- Postoperative levonorgestrel‐releasing intrauterine system versus oral contraceptives after gonadotropin‐releasing hormone agonist treatment for preventing endometrioma recurrence via openalex
- Postoperative maintenance levonorgestrel-releasing intrauterine system and endometrioma recurrence: a randomized controlled study via openalex
- Progesterone Receptor Isoform A But Not B Is Expressed in Endometriosis via openalex
- Progesterone resistance in endometriosis is modulated by the altered expression of microRNA-29c and FKBP4 via openalex
- Progestins for Symptomatic Endometriosis: Results of Clinical Studies via openalex
- Prostaglandin E<sub>2</sub>Stimulates Aromatase Expression in Endometriosis-Derived Stromal Cells<sup>1</sup> via openalex
- Reduced pelvic pain in women with endometriosis: efficacy of long-term dienogest treatment via openalex
- Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain via openalex
- The dynamics of nuclear receptors and nuclear receptor coregulators in the pathogenesis of endometriosis via openalex
- The efficacy, side-effects and continuation rates in women with symptomatic endometriosis undergoing treatment with an intra-uterine administered progestogen (levonorgestrel): a 3 year follow-up via openalex
- The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the disease via openalex
- The levonorgestrel-releasing intrauterine device reduces CA-125 serum levels in patients with endometriosis via openalex
- The role of the levonorgestrel-releasing intrauterine device in the management of symptomatic endometriosis via openalex
- Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex
- W1569704074 via openalex
- W2994812398 via openalex
- W1525342509 via openalex
- W2101744447 via openalex
- W151949596 via openalex
- W2104687197 via openalex
- W2101417341 via openalex
- W2131027406 via openalex
- W2095424038 via openalex
- W2077644752 via openalex
- W2065223935 via openalex
- W2228635764 via openalex
- W2041320907 via openalex
- W2033143591 via openalex
- W2586772905 via openalex
- W1990483217 via openalex
- W1984784419 via openalex
- W1978085719 via openalex
- W1969489572 via openalex
Cited by (25)
- Effects of vitamin supplementation on related symptoms in women with endometriosis: a systematic review and meta-analysis 2025
- A comprehensive review comparing conventional versus traditional remedies in the treatment of endometriosis with futuristic insights 2024
- Comparison of the clinical efficacy of dienogest and drospirone/ethinyl estradiol in the treatment of ovarian endometriosis cysts 2024
- Use of the Drospirenone-Only Contraceptive Pill in Adolescents with Endometriosis 2024
- Nuevas perspectivas en el abordaje farmacológico del dolor en mujeres con endometriosis. 2023
- Exploring Patient Adherence to Post-Surgical Follow-Up in Pelvic Endometriosis 2023
- Evaluation and management of endometriosis 2023
- Roles of microRNAs in Regulating Apoptosis in the Pathogenesis of Endometriosis 2022
- Medical Treatment of Adenomyosis 2022
- Phrenic nerve paralysis after bipolar electrocoagulation of endometriosis of the diaphragm: case report and mini review 2022
- Pathogenesis of Endometriosis: Progesterone Resistance in Women with Endometriosis 2022
- Effects of risk factors for ovarian cancer in women with and without endometriosis 2022
- Regulation of progesterone receptor expression in endometriosis, endometrial cancer, and breast cancer by estrogen, polymorphisms, transcription factors, epigenetic alterations, and ubiquitin-proteasome system 2022
- Medical treatments of endometriosis: a review 2022
- The issues of endometriosis hormonal treatment in reproductive age women 2022
- EXPERIENCE OF LONG-TERM USE OF DIENOGEST FOR THE TREATMENT OF ADENOMYOSIS 2021
- Endometriosis: impact on fertility and pregnancy outcomes 2021
- Pharmacology of Endometriosis 2021
- The effect of dydrogesterone on sexual function in endometriosis 2021
- The role of mitogen‐activated protein kinase signaling pathway in endometriosis 2021
- Effect of<scp>epigallocatechin‐3‐gallate</scp>on the status of<scp>DNA</scp>methylation of E‐cadherin promoter region on endometriosis mouse 2020
- The Effect of Surgical Intervention of Endometriosis to CA-125 and Pain 2020
- Medical Management of Endometriosis, Present and Future with Special Reference to MHT in the Patient Previously Diagnosed with Endometriosis 2020
- Hormonal Therapy in Women of Reproductive Age with Endometriosis: an Update 2019
- Clinical presentation and treatment of catameinal pneumothorax and endometriosis-related pneumothorax 2018
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:19:37.156494+00:00
License: CC0
· commercial use OK