Effect ofepigallocatechin‐3‐gallateon the status ofDNAmethylation of E‐cadherin promoter region on endometriosis mouse

Qi‐Hui Guan, Qi-Hui Guan, Wen-Jing Shi, Wenjing Shi, Long-Shu Zhou, Long‐Shu Zhou, Ai-Lin Tao, Ailin Tao, Lu Li
Journal of Obstetrics and Gynaecology Research · 2020 · vol. 46(10) , pp. 2076–2083 · doi:10.1111/jog.14358 · PMID:32840012 · W3081437414
article OA: closed CC0 ⤵ 5 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Epigallocatechin-3-gallate was found to inhibit endometriosis lesion growth in mice, decrease E-cadherin promoter DNA methylation, and increase E-cadherin expression compared to controls.

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Abstract

AIM: To evaluate whether epigallocatechin-3-gallate acts on endometriosis mouse, and changes the status of DNA methylation of E-cadherin promoter region. METHODS: According to our previous research, the tracing nude mouse model of endometriosis was built up and randomly divided into three groups: control group (group A), epigallocatechin-3-gallate group (group B) and decitabine group (group C). Normal saline, epigallocatechin-3-gallate and decitabine were isometrically intraperitoneally injected into each group once in 2 days. In this period, the growth situations of lesions were monitored by living image system. After 16 days, the lesions were taken out and the distribution of E-cadherin and its methylated situation of promoter region were analyzed. RESULTS: The region of interest of ectopic lesion increased from 4th to 16th day in group A (P < 0.01); in group B and C, the region of interest of ectopic lesion increased in the 0-8th day (P < 0.01), and decreased in the 8-16th day (P < 0.01). The positive expression rate of E-cadherin in group C was higher than group B, and group B was higher than group A (P < 0.01). The DNA methylation status of E-cadherin promoter region in group A was higher than group B, and group B was higher than group C (P < 0.01). CONCLUSION: Epigallocatechin-3-gallate may inhibit the growth of endometrial lesion, affect the expression of E-cadherin on the cell membrane and reduce the status of DNA methylation of E-cadherin promoter region.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

DNA Methylation Endometriosis Endometriosis Endometriosis Animals Cadherins Cadherins Catechin Catechin Female Humans Mice Mice, Nude Promoter Regions, Genetic

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (45)

Cited by (5)

SciLite annotations

chemicals 6
theaflavin-3-gallate theaflavin-3-gallate theaflavin-3-gallate ancitabine theaflavin-3-gallate ancitabine
organisms 2
transgenic mice transgenic mice

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