Effect of epigallocatechin-3-gallate on the status of DNA methylation of E-cadherin promoter region on endometriosis mouse

Qi-Hui Guan, Qi‐Hui Guan, Guan QH, Shi WJ, Wen-Jing Shi, Wenjing Shi, Zhou LS, Long-Shu Zhou, Long‐Shu Zhou, Tao AL, Ailin Tao, Ai-Lin Tao, Lu Li, Li L
Journal of Obstetrics and Gynaecology Research · 2020 · vol. 46(10) , pp. 2076–2083 · doi:10.1111/jog.14358 · PMID:32840012 · W3081437414
Lab / animal OA: closed CC0 ⤵ 5 in-corpus citations
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Epigallocatechin-3-gallate was found to inhibit endometriosis lesion growth in mice, decrease E-cadherin promoter DNA methylation, and increase E-cadherin expression compared to controls.

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Abstract

AIM: To evaluate whether epigallocatechin-3-gallate acts on endometriosis mouse, and changes the status of DNA methylation of E-cadherin promoter region. METHODS: According to our previous research, the tracing nude mouse model of endometriosis was built up and randomly divided into three groups: control group (group A), epigallocatechin-3-gallate group (group B) and decitabine group (group C). Normal saline, epigallocatechin-3-gallate and decitabine were isometrically intraperitoneally injected into each group once in 2 days. In this period, the growth situations of lesions were monitored by living image system. After 16 days, the lesions were taken out and the distribution of E-cadherin and its methylated situation of promoter region were analyzed. RESULTS: The region of interest of ectopic lesion increased from 4th to 16th day in group A (P < 0.01); in group B and C, the region of interest of ectopic lesion increased in the 0-8th day (P < 0.01), and decreased in the 8-16th day (P < 0.01). The positive expression rate of E-cadherin in group C was higher than group B, and group B was higher than group A (P < 0.01). The DNA methylation status of E-cadherin promoter region in group A was higher than group B, and group B was higher than group C (P < 0.01). CONCLUSION: Epigallocatechin-3-gallate may inhibit the growth of endometrial lesion, affect the expression of E-cadherin on the cell membrane and reduce the status of DNA methylation of E-cadherin promoter region.

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Condition tags

endometriosis

MeSH descriptors

DNA Methylation DNA Methylation Endometriosis Endometriosis Endometriosis Endometriosis Animals Animals Cadherins Cadherins Cadherins Catechin Catechin Catechin Female Female Humans Humans Mice Mice

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (45)

Cited by (6)

SciLite annotations

chemicals 6
theaflavin-3-gallate theaflavin-3-gallate theaflavin-3-gallate ancitabine theaflavin-3-gallate ancitabine
organisms 2
transgenic mice transgenic mice

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