Oxidative DNA damage may promote the development of endometriosis by activating telomerase and extending telomere length: a meta-analysis

Hailan He, Huanli He, Xiao‐Hui Yang, Xiaohui Yang, Kai Wang, Qingjian Ye
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2025 · vol. 30(6) , pp. 428–442 · doi:10.1080/1354750x.2025.2557452 · PMID:40905409 · W4413989961
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This meta-analysis found that elevated 8-OHdG, telomerase activity, hTERT, and longer telomere length are associated with an increased risk of endometriosis.

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Abstract

OBJECTIVE: To investigate the associations between oxidative DNA damage biomarkers (levels of 8-hydroxy-2'-deoxyguanosine [8-OHdG], telomere length [TL], human telomerase reverse transcriptase [hTERT], telomerase activity [TA] and polymorphisms of human 8-oxoguanine glycosylase 1 [hOGG1] or X-ray repair cross-complementing group 4 [XRCC4]) and endometriosis (EMT) by a meta-analysis. METHODS: Five databases were searched until August 2024. Stata version 15.0 was used to estimate pooled odds ratio (OR) or standardized mean difference (SMD) with 95% confidence intervals (CIs). RESULTS: G: OR = 3.49; 95%CI = 2.27-5.35) of XRCC4 rs6869366 had a higher risk of developing EMT. Subgroup and trim-and-fill analyses indicated longer TL was a risk factor for EMT. CONCLUSIONS: 8-OHdG, TA, hTERT, TL, rs1052133 and rs6869366 represent potential prediction biomarkers and treatment targets for EMT.

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Condition tags

endometriosis

MeSH descriptors

DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (54)

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