Oxidative DNA damage may promote the development of endometriosis by activating telomerase and extending telomere length: a meta-analysis

Huanli He, He H, Hailan He, Xiao‐Hui Yang, Xiaohui Yang, Yang X, Wang K, Kai Wang, Qingjian Ye, Ye Q
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2025 · vol. 30(6) , pp. 428–442 · doi:10.1080/1354750x.2025.2557452 · PMID:40905409 · W4413989961
meta-analysis OA: closed CC0
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This meta-analysis found that elevated 8-OHdG, telomerase activity, hTERT, and longer telomere length are associated with an increased risk of endometriosis.

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Abstract

OBJECTIVE: To investigate the associations between oxidative DNA damage biomarkers (levels of 8-hydroxy-2'-deoxyguanosine [8-OHdG], telomere length [TL], human telomerase reverse transcriptase [hTERT], telomerase activity [TA] and polymorphisms of human 8-oxoguanine glycosylase 1 [hOGG1] or X-ray repair cross-complementing group 4 [XRCC4]) and endometriosis (EMT) by a meta-analysis. METHODS: Five databases were searched until August 2024. Stata version 15.0 was used to estimate pooled odds ratio (OR) or standardized mean difference (SMD) with 95% confidence intervals (CIs). RESULTS: Forty-two studies were included. Overall meta-analysis revealed significantly elevated 8-OHdG (SMD = 1.84; 95%CI = 1.29-2.39), TA (SMD = 3.03; 95%CI = 2.07-4.00) and hTERT (SMD = 2.55; 95%CI = 1.55-3.55) in EMT women compared to controls. Women carrying GG genotype (vs. GC+CC: OR = 1.34; 95%CI = 1.00-1.78) of hOGG1 rs1052133, TT genotype (vs. TG+GG: OR = 2.67; 95%CI = 1.63-4.38) and T allele (vs. G: OR = 3.49; 95%CI = 2.27-5.35) of XRCC4 rs6869366 had a higher risk of developing EMT. Subgroup and trim-and-fill analyses indicated longer TL was a risk factor for EMT. CONCLUSIONS: 8-OHdG, TA, hTERT, TL, rs1052133 and rs6869366 represent potential prediction biomarkers and treatment targets for EMT.
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Abstract

Objective To investigate the associations between oxidative DNA damage biomarkers (levels of 8-hydroxy-2’-deoxyguanosine [8-OHdG], telomere length [TL], human telomerase reverse transcriptase [hTERT], telomerase activity [TA] and polymorphisms of human 8-oxoguanine glycosylase 1 [hOGG1] or X-ray repair cross-complementing group 4 [XRCC4]) and endometriosis (EMT) by a meta-analysis.

Methods

Five databases were searched until August 2024. Stata version 15.0 was used to estimate pooled odds ratio (OR) or standardized mean difference (SMD) with 95% confidence intervals (CIs).

Results

Forty-two studies were included. Overall meta-analysis revealed significantly elevated 8-OHdG (SMD = 1.84; 95%CI = 1.29–2.39), TA (SMD = 3.03; 95%CI = 2.07–4.00) and hTERT (SMD = 2.55; 95%CI = 1.55–3.55) in EMT women compared to controls. Women carrying GG genotype (vs. GC+CC: OR = 1.34; 95%CI = 1.00–1.78) of hOGG1 rs1052133, TT genotype (vs. TG+GG: OR = 2.67; 95%CI = 1.63–4.38) and T allele (vs. G: OR = 3.49; 95%CI = 2.27–5.35) of XRCC4 rs6869366 had a higher risk of developing EMT. Subgroup and trim-and-fill analyses indicated longer TL was a risk factor for EMT.

Conclusions

8-OHdG, TA, hTERT, TL, rs1052133 and rs6869366 represent potential prediction biomarkers and treatment targets for EMT. Author contributions Huanli He: Conceptualization, Data curation, Formal analysis, Writing – original draft. Xiaohui Yang: Data curation, Writing – original draft. Kai Wang: Conceptualization, Supervision, Writing - review & editing. Qingjian Ye: Conceptualization, Supervision, Writing – review & editing. Availability of data and materials The used data are displayed in Table S1 and collected from Supplementary information.

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Condition tags

endometriosis

MeSH descriptors

DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage DNA Damage

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (54)

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